推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
分子量
antigen ~50 kDa
种属反应性
human
包装
vial of 2 mL lyophilized antiserum
技术
immunoelectrophoresis: suitable
indirect ELISA: 1:30,000-1:60,000
UniProt登记号
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... SERPINA1(5265)
一般描述
α-1-抗胰蛋白酶属于丝酶抑制蛋白家族，是一种活性很强的丝氨酸蛋白酶抑制剂。其关键作用是保护下呼吸道免受人白细胞弹性蛋白酶的水解破坏。AAT基因突变会降低血清中α-1-抗胰蛋白酶的浓度，从而增加患肺气肿的风险。α1-抗胰蛋白酶抗体（以1:9000稀释）可用作测定转基因表达水平的捕获抗体。它也可用于免疫电泳。兔抗α1-抗胰蛋白酶抗体可与人α1-抗胰蛋白酶发生特异性反应。
免疫原
纯化人 α-1-抗胰蛋白酶
应用
α1-抗胰蛋白酶抗体（以1∶1000稀释）可用于ELISA。它也可用于探测免疫印迹以鉴定A1AT。另外，它还可用于Ouchterlony双向扩散法。
兔抗 α1-抗胰蛋白酶抗体也可用于免疫电泳技术。
此抗体已成功使用的应用，以及相关的同行评审论文如下。
蛋白免疫分析（Western Blotting）（1篇文章）
蛋白免疫分析（Western Blotting）（1篇文章）
外形
0.01 M 磷酸盐缓冲盐水 (pH 7.2) 冻干。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Mengjun Wang et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 26(5), 795-803 (2017-02-23)
Background: Hepatocellular carcinoma (HCC) has the greatest increase in mortality among all solids tumors in the United States related to low rates of early tumor detection. Development of noninvasive biomarkers for the early detection of HCC may reduce HCC-related mortality.Methods:
Joerg Schuettrumpf et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 13(1), 88-97 (2005-10-19)
Identifying factors that influence gene transfer efficacy is critical for a successful gene-based clinical study. Here we demonstrate that in vivo AAV-2-mediated gene transfer is efficiently inhibited by unfractionated heparin, but not by a heparin preparation containing mainly low-molecular-weight forms
Mingming Gao et al.
Scientific reports, 9(1), 13427-13427 (2019-09-19)
Obesity and associated metabolic comorbidities represent a growing public health problem. In this study, we demonstrate the use of a newly created fusion gene of exendin-4 and α1-antitrypsin to control obesity and obesity-associated metabolic disorders including insulin resistance, fatty liver
James K Stoller et al.
American journal of respiratory and critical care medicine, 185(3), 246-259 (2011-10-01)
α(1)-Antitrypsin (AAT) deficiency is an underrecognized genetic condition that affects approximately 1 in 2,000 to 1 in 5,000 individuals and predisposes to liver disease and early-onset emphysema. AAT is mainly produced in the liver and functions to protect the lung
Michael J Iannotti et al.
ACS chemical biology, 14(3), 497-505 (2019-01-31)
Nearly one-third of the encoded proteome is comprised of secretory proteins that enable communication between cells and organ systems, playing a ubiquitous role in human health and disease. High-throughput detection of secreted proteins would enhance efforts to identify therapies for
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