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安全信息

A023

Sigma-Aldrich

2-(Methylthio)adenosine 5′-triphosphate tetrasodium salt hydrate

solid, ≥90%

别名:

2-MeSATP, 2-Methylthio-ATP tetrasodium salt hydrate

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About This Item

经验公式（希尔记法）:
C11H14N5Na4O13P3S · xH2O
分子量:
641.20 (anhydrous basis)
MDL编号:
MFCD00069196
UNSPSC代码:
12352200
PubChem化学物质编号:
24277689

方案

≥90%

表单

solid

储存条件

desiccated

颜色

white

溶解性

H2O: 13 mg/mL (Solutions should be freshly prepared.)

εmax

15,100 at 274 nm
20,900 at 233.4 nm

运输

dry ice

储存温度

−70°C

SMILES字符串

[Na+].[Na+].[Na+].[Na+].CSc1nc(N)c2ncn([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]3O)c2n1

InChI

1S/C11H18N5O13P3S.4Na/c1-33-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1

InChI key

UEEFBRHXFDJPTA-KWIZKVQNSA-J

基因信息

human ... LPAR4(2846) , LTB4R(1241) , P2RY1(5028) , P2RY10(27334) , P2RY11(5032) , P2RY12(64805) , P2RY13(53829) , P2RY14(9934) , P2RY2(5029) , P2RY4(5030) , P2RY5(10161) , P2RY6(5031) , P2RY8(286530)

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生化/生理作用

2-Methylthioadenosine triphosphate is a potent P2Y purinoceptor agonist.

注意

Hygroscopic.

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
068K46203
068K46202
068K46201
068K4620
066K4712

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Melanie J Ludlow et al.
Cell calcium, 44(6), 567-579 (2008-05-20)
The presence of five P2X-like genes (p2xA-E) in Dictyostelium suggests that nucleotides other than cAMP may act as extracellular signalling molecules in this model eukaryote. However, p2xA was found to have an exclusively intracellular localisation making it unclear whether Dictyostelium
Peter D J Thornton et al.
PloS one, 8(2), e40840-e40840 (2013-02-06)
The nature of synaptic transmission at functionally distinct synapses in intestinal reflex pathways has not been fully identified. In this study, we investigated whether transmission between interneurons in the descending inhibitory pathway is mediated by a purine acting at P2Y
R Preston Mason et al.
BMC pharmacology & toxicology, 14, 48-48 (2013-10-01)
Nebivolol is a third-generation beta-blocker used to treat hypertension. The vasodilation properties of nebivolol have been attributed to nitric oxide (NO) release. However, the kinetics and mechanism of nebivolol-stimulated bioavailable NO are not fully understood. Using amperometric NO and peroxynitrite
N J Cusack et al.
British journal of pharmacology, 75(2), 397-400 (1982-02-01)
Some 2-alkylthio derivatives of adenosine 5'-monophosphate (AMP), adenosine 5'-monophosphorothioate (AMPS) and adenosine 5'-triphosphate (ATP) were examined as inhibitors of human platelet aggregation. 2-Methylthio-AMP, 2-ethylthio-AMP, 2-(pentan-l-yl)thio-AMP, 2-ethylthio-AMPS, 2-methylthio-ATP and 2-ethylthio-ATP (100 microM) each inhibited aggregation induced by adenosine 5'-diphosphate (ADP) but
G Burnstock et al.
British journal of pharmacology, 79(4), 907-913 (1983-08-01)
ATP, 2-chloro-ATP, 2-methylthio-ATP, and their unnatural L-enantiomers, were synthesized and their effects tested on the guinea-pig taenia coli and urinary bladder, and the stimulated frog ventricle. The potent P2-purinoceptor agonists, 2-chloro-ATP and 2-methylthio-ATP were, respectively, 30 and 200 times more
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