SML0475

CGP36742

Name: CGP36742
Brand: SIGMA

≥97% (NMR)

别名:

P-(3-Aminopropyl)-P-butyl-phosphinic acid, SGS 742

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关于此项目

经验公式（希尔记法）:

C₇H₁₈NO₂P

化学文摘社编号:

123690-78-8

分子量:

179.20

NACRES:

NA.77

PubChem Substance ID:

329825430

UNSPSC Code:

12352200

MDL number:

MFCD00882735

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产品名称

CGP36742, ≥97% (NMR)

InChI

1S/C7H18NO2P/c1-2-3-6-11(9,10)7-4-5-8/h2-8H2,1H3,(H,9,10)

SMILES string

CCCCP(O)(=O)CCCN

InChI key

ONNMDRQRSGKZCN-UHFFFAOYSA-N

assay

≥97% (NMR)

form

powder

storage condition

desiccated

color

white to beige

solubility

H₂O: 10 mg/mL (clear solution, warmed)

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

CGP36742 is a GABAB receptor antagonist.

CGP36742 was the first orally active GABAB-selective antagonist. The IC₅₀ for blocking GABAergic transmission is 36 μM. Oral administration of CGP36742 in rats blocks baclofen-induced neuronal depression, and reduces learning deficit and passive avoidance in an olfactory bulbectomy depression model.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.