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安全信息

SML0042

Sigma-Aldrich

Lazabemide hydrate

≥97% (HPLC)

别名:

N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrate, Ro 19-6327 hydrate

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100 G
CN¥911.90
250 G
CN¥1,306.12
500 G
CN¥2,444.50
1 KG
CN¥4,264.48
5 KG
CN¥15,273.54
10 KG
CN¥25,522.00
25 KG
CN¥43,648.17
25 KG
CN¥58,613.10

CN¥911.90

国内现货，预计发货时间April 25, 2025详情

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选择尺寸

变更视图
100 G
CN¥911.90
250 G
CN¥1,306.12
500 G
CN¥2,444.50
1 KG
CN¥4,264.48
5 KG
CN¥15,273.54
10 KG
CN¥25,522.00
25 KG
CN¥43,648.17
25 KG
CN¥58,613.10

About This Item

经验公式（希尔记法）:
C8H10ClN3O · xH2O
CAS号:
103878-84-8
分子量:
199.64 (anhydrous basis)
MDL编号:
MFCD20488051
UNSPSC代码:
12352200
PubChem化学物质编号:
329825112
NACRES:
NA.77

CN¥911.90

国内现货，预计发货时间April 25, 2025详情

质量水平

100

方案

≥97% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to tan

溶解性

DMSO: ≥22 mg/mL

创始人

Roche

储存温度

room temp

SMILES字符串

O.NCCNC(=O)c1ccc(Cl)cn1

InChI

1S/C8H10ClN3O.H2O/c9-6-1-2-7(12-5-6)8(13)11-4-3-10;/h1-2,5H,3-4,10H2,(H,11,13);1H2

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Trizma® hydrochloride

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Trizma® hydrochloride BioXtra, pH 3.5-5.0 (0.5 M in H2O), ≥99.0% (titration)

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Trizma® hydrochloride

technique(s)

affinity chromatography: suitable

technique(s)

DNA purification: suitable, cell culture | mammalian: suitable, electrophoresis: suitable, protein extraction: suitable

technique(s)

-

technique(s)

-

assay

≥99.0% (titration)

assay

≥99.0% (titration)

assay

≥99%

assay

≥99.0% (titration)

grade

reagent grade

grade

BioPerformance Certified

grade

reagent grade

grade

-

Quality Level

400

Quality Level

400

Quality Level

200

Quality Level

400

application(s)

diagnostic assay manufacturing
life science and biopharma
sample preparation

application(s)

diagnostic assay manufacturing
general analytical
life science and biopharma
sample preparation

application(s)

-

application(s)

diagnostic assay manufacturing

form

crystalline

form

crystalline powder

form

crystalline

form

powder

应用

Lazabemide hydrate may be used in cell signaling studies.

生化/生理作用

Lazabemide is a selective and reversible monoamine oxidase B (MAO-B) inhibitor and Anti-Parkinson. Also it inhibits monoamine uptake at high concentrations (IC50 values are 86, 123 and > 500 μM for noradrenalin, serotonin and dopamine uptake respectively).
Lazabemide is effective in treatment of Alzheimer′s disease[1] and in combination with nicotine replacement therapy aids in smoking cessation.[2]
Selective MAO-B inhibitor; Antiparkinson

特点和优势

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302,H319

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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    分析证书(COA)

    Lot/Batch Number
    071M4718V

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    Lazabemide for the treatment of Alzheimer's disease: rationale and therapeutic perspectives.
    A M Cesura et al.
    Advances in neurology, 80, 521-528 (1999-07-20)
    R Raddatz et al.
    The Journal of pharmacology and experimental therapeutics, 292(3), 1135-1145 (2000-02-25)
    A series of phenoxy-substituted methylimidazoline derivatives were synthesized and used to define the ligand recognition properties of the imidazoline-binding domain (IBD) on monoamine oxidase (MAO)-B and its role in substrate processing. The rank order of potency for selected compounds in
    Andrzej Dekundy et al.
    Journal of neural transmission (Vienna, Austria : 1996), 118(12), 1703-1716 (2010-12-17)
    Subtype 5 metabotropic glutamate receptors (mGluR5) are abundant in the basal ganglia, amygdala, septum, hippocampus, peripheral sensory neurones and dorsal horn of the spinal cord. Thus, mGluR5 has been implicated in central processes underlying movement control, emotion, learning, and nociception.
    Ivan Berlin et al.
    Addiction (Abingdon, England), 97(10), 1347-1354 (2002-10-03)
    Previous research has shown that smokers have reduced brain and platelet monoamine oxidase B (MAOB) activity. This is probably due to some components of tobacco smoke. When smokers quit, MAOB activity returns to normal. Reduced MAO activity may increase nicotine's
    N Andrés et al.
    Neuroscience, 101(4), 807-810 (2000-12-13)
    Aged rats may be behaviorally classified as either cognitively impaired or unimpaired based upon their performance in the Morris water maze task. In aged Long-Evans rats, emergence of functional deficits has been related to the increase in the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic
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