Monoclonal Anti-SERCa2 ATPase antibody produced in mouse

SERCa2 ATPase (sarco/endoplasmic reticulum calcium-ATPase 2) is also known as ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). It codes for SERCA2a and SERCA2b, that are expressed in all tissues. SERCA2a is highly expressed in heart. SERCa2 is located on human chromosome 12q24.1.

canine cardiac sarcoplasmic reticulum vesicles

Anti-SERCa2 ATPase antibody has been used in western blotting and immunocytochemistry.

Mutation of SERCa2 ATPase (sarco/endoplasmic reticulum calcium-ATPase 2) or ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca²⁺ transporting 2) causes Dyskeratosis follicularis. SERCA2a plays a major role in controlling cardiomyocyte Ca²⁺. ATP2A2 mutation may cause Darier disease (DD).

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