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安全信息

R106

Sigma-Aldrich

Ro 16-6491 hydrochloride

solid

别名:

N-(2-Aminoethyl)-4-chlorobenzamide hydrochloride

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250 μG
¥4,489.38

¥4,489.38

预计发货时间2025年5月16日详情

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250 μG
¥4,489.38

About This Item

经验公式（希尔记法）:
C9H11ClN2O · HCl
CAS号:
94319-79-6
分子量:
235.11
MDL编号:
MFCD00078595
UNSPSC代码:
12352200
PubChem化学物质编号:
329823996

¥4,489.38

预计发货时间2025年5月16日详情

表单

solid

颜色

white

mp

216-217 °C

溶解性

H2O: soluble

SMILES字符串

Cl.NCCNC(=O)c1ccc(Cl)cc1

InChI

1S/C9H11ClN2O.ClH/c10-8-3-1-7(2-4-8)9(13)12-6-5-11;/h1-4H,5-6,11H2,(H,12,13);1H

InChI key

ARUMZUNJBHSOQQ-UHFFFAOYSA-N

基因信息

human ... MAOB(4129)

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此商品
A9511A4327A8301
Albumin from human serum lyophilized powder, ≥96% (agarose gel electrophoresis)

A1653

Albumin from human serum

Albumin from human serum lyophilized powder, ≥97% (agarose gel electrophoresis)

A9511

Albumin from human serum

Albumin from human serum lyophilized powder, essentially protease free, ≥96% (agarose gel electrophoresis)

A4327

Albumin from human serum

Albumin, glycated human lyophilized powder

A8301

Albumin, glycated human

assay

≥96% (agarose gel electrophoresis)

assay

≥97% (agarose gel electrophoresis)

assay

≥96% (agarose gel electrophoresis)

assay

90-100% protein basis (biuret)

biological source

human

biological source

human

biological source

human

biological source

human

technique(s)

ELISA: suitable, western blot: suitable, tissue culture: suitable

technique(s)

ELISA: suitable, tissue culture: suitable, western blot: suitable

technique(s)

tissue culture: suitable

technique(s)

cell culture | mammalian: suitable

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

200

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

impurities

HIV I and HIVII, HCV and HBsAg, tested negative

impurities

HIV I and HIVII, HCV and HBsAg, tested negative

impurities

HIV I and HIVII, HCV and HBsAg, tested negative

impurities

-

生化/生理作用

Selective, reversible, orally-active MAO-B inhibitor which is devoid of indirect sympathomimetic activity.

可比产品

产品编号
说明
价格

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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    H H Keller et al.
    Naunyn-Schmiedeberg's archives of pharmacology, 335(1), 12-20 (1987-01-01)
    The inhibition of monoamine oxidase (MAO) in rat liver and brain by the short-acting MAO-A inhibitors moclobemide (Ro 11-1163 = p-chloro-N-[2-morpholinoethyl]benzamide) and brofaremine and by the short-acting MAO-B inhibitors Ro 16-6491 (N-[2-aminoethyl]-p-chloro-benzamide) and almoxatone, administered p.o. at roughly equieffective doses
    Xi Jun He et al.
    Neurotoxicology, 29(6), 1141-1146 (2008-07-09)
    Neurotoxic effects of MPTP on the nigrostriatal dopaminergic system are thought to be initiated by 1-methyl-4-phenylpyridinium (MPP+), a metabolite formed by the monoamine oxidase (MAO)-B-mediated oxidation of MPTP. We previously reported that the administration of MPTP induced apoptosis in migrating
    A M Cesura et al.
    Journal of neural transmission. Supplementum, 32, 165-170 (1990-01-01)
    The selective, reversible inhibitors of monoamine oxidase (MAO) moclobemide and Ro 41-1049 (selective for MAO-A), as well as of Ro 16-6491 and Ro 19-6327 (selective for MAO-B) inhibited the enzyme with an initial competitive phase, followed by a time-dependent inhibition
    A M Cesura et al.
    European journal of pharmacology, 162(3), 457-465 (1989-03-29)
    This study demonstrated the existence of specific binding sites for [3H]Ro 19-6327 in human platelet membranes. This compound is a novel, time-dependent inhibitor of monoamine oxidase type B (MAO-B) and is structurally closely related to [3H]Ro 16-6491. The density of
    G E Handelmann et al.
    Pharmacology, biochemistry, and behavior, 34(4), 823-828 (1989-12-01)
    The N-methyl-D-aspartate receptor complex appears to play an important role in processes of learning and memory. The presence of a glycine modulatory site at this complex has recently been established and suggests that glycinergic neurotransmission may influence these cognitive functions.
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