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P118

Sigma-Aldrich

法洛芬

solid

别名:

3-氨基-2-（4-氯苯基）丙烷膦酸

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25 G
CN¥839.76
100 G
CN¥2,270.62

CN¥839.76

国内现货，预计发货时间April 10, 2025详情

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25 G
CN¥839.76
100 G
CN¥2,270.62

About This Item

经验公式（希尔记法）:
C9H13ClNO3P
CAS号:
114012-12-3
分子量:
249.63
MDL编号:
MFCD00069328
UNSPSC代码:
12352200
PubChem化学物质编号:
24278189
NACRES:
NA.32

CN¥839.76

国内现货，预计发货时间April 10, 2025详情

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表单

solid

杂质

≥97% (NMR)

颜色

white

溶解性

0.1 M HCl: 13.3 mg/mL
methanol: 19.3 mg/mL
DMSO: insoluble

SMILES字符串

NCC(CP(O)(O)=O)c1ccc(Cl)cc1

InChI

1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)

InChI key

VSGNGLJPOGUDON-UHFFFAOYSA-N

基因信息

human ... GABBR1(2550) , GABBR2(9568)

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此商品
379891P787577310
Periodic acid ACS reagent, 99%

375810

Periodic acid

Periodic acid 99.999% trace metals basis

379891

Periodic acid

Periodic acid ReagentPlus®, ≥99.0%

P7875

Periodic acid

Periodic acid puriss. p.a., ACS reagent, crystallized, ≥99.0% (RT)

77310

Periodic acid

assay

99%, 99.0-101.0% (ACS specification)

assay

99.999% trace metals basis

assay

≥99.0%

assay

≥99.0% (RT)

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

form

powder or crystals

form

crystals

form

powder or crystals

form

powder or crystals

solubility

water: soluble

solubility

water: soluble

solubility

water: 100 mg/mL, clear, colorless

solubility

water: soluble

mp

122 °C (lit.)

mp

122 °C (lit.)

mp

122 °C (lit.)

mp

122 °C (lit.)

一般描述

法克罗芬是巴氯芬的膦酸衍生物。[1]

应用

法克罗芬已用于阻断 GABAB 受体。[2]

生化/生理作用

法克罗芬在鉴定与 GABA 和（−）巴氯芬相互作用的中枢和外周荷包牡丹碱不敏感受体的生理重要性的研究中起着重要作用。[1]法克罗芬可作为 GABAB 受体拮抗剂。法克罗芬具有可逆性阻断已记录在猫和大鼠背外侧膝状核的投射细胞中和大鼠海马 CA1 锥体神经元中的晚的、荷包牡丹碱耐药性、K+ 依赖性抑制性突触后电位（IPSP）的能力。[3]

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000137056
    0000134950
    042M4605V
    066K4603
    084H39003

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    D I Kerr et al.
    Brain research, 405(1), 150-154 (1987-03-03)
    Phaclofen, the phosphonic acid derivative of baclofen, reversibly antagonized the depression of the cholinergic twitch response of the guinea pig ileum and distal colon by either baclofen or GABA. When administered microelectrophoretically, phaclofen reversibly blocked the presumed presynaptic reduction by
    Christof Geigerseder et al.
    Reproductive biology and endocrinology : RB&E, 2, 13-13 (2004-03-26)
    The neurotransmitter gamma-aminobutyric acid (GABA) and subtypes of GABA receptors were recently identified in adult testes. Since adult Leydig cells possess both the GABA biosynthetic enzyme glutamate decarboxylase (GAD), as well as GABA(A) and GABA(B) receptors, it is possible that
    Luminal administration ex vivo of a live Lactobacillus species moderates mouse jejunal motility within minutes.
    Wang B, et al.
    Faseb Journal, 24(10), 4078-4088 (2010)
    Makoto Nishiyama et al.
    Frontiers in synaptic neuroscience, 2, 22-22 (2010-01-01)
    GABAergic interneuronal network activities in the hippocampus control a variety of neural functions, including learning and memory, by regulating θ and γ oscillations. How these GABAergic activities at pre- and postsynaptic sites of hippocampal CA1 pyramidal cells differentially contribute to
    Mohammad Nasehi et al.
    Brain research bulletin, 130, 101-106 (2017-01-24)
    Activation of the GABA
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