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形式
solid
质量水平
杂质
≥97% (NMR)
颜色
white
溶解性
0.1 M HCl: 13.3 mg/mL
methanol: 19.3 mg/mL
DMSO: insoluble
SMILES字符串
NCC(CP(O)(O)=O)c1ccc(Cl)cc1
InChI
1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)
InChI key
VSGNGLJPOGUDON-UHFFFAOYSA-N
基因信息
human ... GABBR1(2550) , GABBR2(9568)
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一般描述
法克罗芬是巴氯芬的膦酸衍生物。
应用
法克罗芬已用于阻断 GABAB 受体。
生化/生理作用
法克罗芬在鉴定与 GABA 和（−）巴氯芬相互作用的中枢和外周荷包牡丹碱不敏感受体的生理重要性的研究中起着重要作用。法克罗芬可作为 GABAB 受体拮抗剂。法克罗芬具有可逆性阻断已记录在猫和大鼠背外侧膝状核的投射细胞中和大鼠海马 CA1 锥体神经元中的晚的、荷包牡丹碱耐药性、K+ 依赖性抑制性突触后电位（IPSP）的能力。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Christof Geigerseder et al.
Reproductive biology and endocrinology : RB&E, 2, 13-13 (2004-03-26)
The neurotransmitter gamma-aminobutyric acid (GABA) and subtypes of GABA receptors were recently identified in adult testes. Since adult Leydig cells possess both the GABA biosynthetic enzyme glutamate decarboxylase (GAD), as well as GABA(A) and GABA(B) receptors, it is possible that
Makoto Nishiyama et al.
Frontiers in synaptic neuroscience, 2, 22-22 (2010-01-01)
GABAergic interneuronal network activities in the hippocampus control a variety of neural functions, including learning and memory, by regulating θ and γ oscillations. How these GABAergic activities at pre- and postsynaptic sites of hippocampal CA1 pyramidal cells differentially contribute to
Luminal administration ex vivo of a live Lactobacillus species moderates mouse jejunal motility within minutes.
Wang B, et al.
Faseb Journal, 24(10), 4078-4088 (2010)
Mohammad Nasehi et al.
Brain research bulletin, 130, 101-106 (2017-01-24)
Activation of the GABA
D I Kerr et al.
Brain research, 405(1), 150-154 (1987-03-03)
Phaclofen, the phosphonic acid derivative of baclofen, reversibly antagonized the depression of the cholinergic twitch response of the guinea pig ileum and distal colon by either baclofen or GABA. When administered microelectrophoretically, phaclofen reversibly blocked the presumed presynaptic reduction by
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