P118
法洛芬
solid
别名:
3-氨基-2-（4-氯苯基）丙烷膦酸
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C9H13ClNO3P
化学文摘社编号:
分子量:
249.63
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
法洛芬, solid
InChI key
VSGNGLJPOGUDON-UHFFFAOYSA-N
SMILES string
NCC(CP(O)(O)=O)c1ccc(Cl)cc1
InChI
1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)
form
solid
impurities
≥97% (NMR)
color
white
solubility
0.1 M HCl: 13.3 mg/mL
methanol: 19.3 mg/mL
DMSO: insoluble
Quality Level
Gene Information
human ... GABBR1(2550), GABBR2(9568)
正在寻找类似产品? 访问 产品对比指南
Application
法克罗芬已用于阻断 GABAB 受体。
Biochem/physiol Actions
法克罗芬在鉴定与 GABA 和（−）巴氯芬相互作用的中枢和外周荷包牡丹碱不敏感受体的生理重要性的研究中起着重要作用。法克罗芬可作为 GABAB 受体拮抗剂。法克罗芬具有可逆性阻断已记录在猫和大鼠背外侧膝状核的投射细胞中和大鼠海马 CA1 锥体神经元中的晚的、荷包牡丹碱耐药性、K+ 依赖性抑制性突触后电位（IPSP）的能力。
General description
法克罗芬是巴氯芬的膦酸衍生物。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
The GABAB antagonist phaclofen inhibits the late K+-dependent IPSP in cat and rat thalamic and hippocampal neurones
Soltesz I, et al.
Brain Research, 448(2), 351-354 (1988)
Kazuo Kunisawa et al.
European journal of pharmacology, 796, 122-130 (2016-12-13)
GABA mediated neuronal system regulates hippocampus-dependent memory and stress responses by controlling plasticity and neuronal excitability. Here, we demonstrate that betaine ameliorates water-immersion restraint stress (WIRS)-induced memory impairments. This improvement was inhibited by a betaine/GABA transporter-1 (GABA transporter-2: GAT2) inhibitor
Effat Ramshini et al.
International journal of preventive medicine, 4(2), 158-164 (2013-04-02)
There is only little information about the effects of GABA receptors agonist and antagonist on morphine self-administration. Present study was designed to assess role of GABAB receptors in the regulation of morphine-reinforced self-administration. THIS STUDY WAS PERFORMED IN FOUR GROUPS
P Dutar et al.
Nature, 332(6160), 156-158 (1988-03-10)
The role of GABA in synaptic transmission in the mammalian central nervous system is more firmly established than for any other neurotransmitter. With virtually every neuron studied, the synaptic action of GABA is mediated by bicuculline-sensitive GABAA receptors which selectively
Phaclofen: a peripheral and central baclofen antagonist
Kerr D I, et al.
Brain Research, 405(1), 150-154 (1987)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持