O7753
草酰乙酸
powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97% (HPLC)
别名:
2-氧代丁二酸, 丁酮二酸, 氧代丁二酸, 草醋酸
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关于此项目
线性分子式:
HOOCCH2COCOOH
化学文摘社编号:
分子量:
132.07
UNSPSC Code:
12352204
NACRES:
NA.75
PubChem Substance ID:
EC Number:
206-329-8
Beilstein/REAXYS Number:
1705475
MDL number:
biological source
synthetic (organic)
Quality Level
product line
BioReagent
assay
≥97% (HPLC)
form
powder
technique(s)
cell culture | insect: suitable, cell culture | mammalian: suitable
solubility
H2O: 100 mg/mL
storage temp.
−20°C
SMILES string
OC(=O)CC(=O)C(O)=O
InChI
1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)
InChI key
KHPXUQMNIQBQEV-UHFFFAOYSA-N
General description
草酰乙酸是一种二羧酸，存在于人体的每个细胞中。它是三羧酸（TCA）循环和糖异生的代谢中间体。
Application
草酰乙酸已用于评价对肌萎缩性侧索硬化症（ALS）模型超氧化物歧化酶1 (SOD1) G93A小鼠神经肌肉功能和寿命的影响。它还被用作杜氏改良Eagles培养基（DMEM）的补充剂，用于培养鸡成纤维细胞（DF-1）和化学永生化来角雄性肝癌（LMH）细胞，以进行功能验证实验。
Biochem/physiol Actions
草酰乙酸在中枢代谢中起重要作用。它可抑制琥珀酸脱氢酶，是线粒体代谢的一种关键调节剂。
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Brian D Fink et al.
The Journal of biological chemistry, 293(51), 19932-19941 (2018-11-06)
We recently reported a previously unrecognized mitochondrial respiratory phenomenon. When [ADP] was held constant ("clamped") at sequentially increasing concentrations in succinate-energized muscle mitochondria in the absence of rotenone (commonly used to block complex I), we observed a biphasic, increasing then
E Esenmo et al.
The American journal of physiology, 263(1 Pt 1), E36-E41 (1992-07-01)
Estimating the rate of hepatic gluconeogenesis in vivo from the incorporation of 14C from 14CO2 into glucose requires determination of the rates in liver of equilibration of oxaloacetate with fumarate, conversion of oxaloacetate to phosphoenolpyruvate (PEP), and conversion of PEP
Eva Brekke et al.
Glia, 60(1), 147-158 (2011-11-05)
Pyruvate carboxylation (PC) is thought to be the major anaplerotic reaction for the tricarboxylic acid cycle and is necessary for de novo synthesis of amino acid neurotransmitters. In the brain, the main enzyme involved is pyruvate carboxylase, which is predominantly
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| O7753-100G | 04061834248521 |
| O7753-5G | 04061835514212 |
| O7753-25G | 04061834248538 |