biological source
Escherichia coli (K-235)
Quality Level
form
lyophilized powder
purified by
phenol extraction
impurities
<3% Protein (Lowry)
color
white to faint yellow
solubility
water: soluble
shipped in
ambient
storage temp.
2-8°C
General description
该产品通过苯酚提取自大肠杆菌血清型K235。源菌株为ATCC 13027。
Application
- Establishment of disseminated intravascular coagulation (DIC) model by a single iv administration of Escherichia coli-derived lipopolysaccharide (LPS) to cynomolgus monkeys and evaluation of its pathophysiological status.：大肠杆菌来源脂多糖(LPS)用于建立弥散性血管内凝血(DIC)食蟹猴模型，解析DIC的病理状态和可能的治疗措施(Minomo et al., 2017)。
- Different bacterial lipopolysaccharides as toxicants and stressors in the shrimp Palaemon elegans.：该文研究各种细菌LPS（包括大肠杆菌K-235）对长臂虾(Palaemon elegans)的毒性作用，促进了解海洋生物的LPS诱导应激反应(Lorenzon et al., 2002)。
Biochem/physiol Actions
脂多糖（LPS）位于膜的外层，并且在非包封的菌株中，其暴露于细胞表面。它们有助于外膜的完整性，并可保护细胞免受胆汁盐和亲脂性抗生素的作用。
Preparation Note
该产品可溶于水（5mg / ml）或细胞培养基（1mg / ml），产生浑浊的淡黄色溶液。当涡旋并升温至70-80 oC后，在盐水中可获得更高浓度的溶液（20mg/ml），但仍然是浑浊的溶液。脂多糖是一种在各种溶剂中都形成胶束的分子。在水和磷酸盐缓冲盐水中可观察到浑浊的溶液。有机溶剂无法使溶液变澄清。甲醇会产生含有漂浮物的混浊悬浮液，而水会产生均匀的混浊溶液。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
Agnieszka Zdybicka-Barabas et al.
Amino acids, 51(2), 175-191 (2018-09-01)
Cecropins constitute an important family of insect antimicrobial peptides involved in humoral innate immune response. In comparison with the highly basic cecropins A and B, cecropins D are less cationic and more hydrophobic. Interestingly, cecropins D were described only in
Jay W Chaplin et al.
The Journal of experimental medicine, 210(10), 2135-2146 (2013-09-11)
Antigen (Ag) targeting is an efficient way to induce immune responses. Ag is usually coupled to an antibody (Ab) specific for a receptor expressed on dendritic cells (DCs), and then the Ag-anti-receptor is inoculated with an adjuvant. Here we report
Jay W Chaplin et al.
Journal of immunology (Baltimore, Md. : 1950), 187(8), 4199-4209 (2011-09-16)
CD180 is homologous to TLR4 and regulates TLR4 signaling, yet its function is unclear. We report that injection of anti-CD180 mAb into mice induced rapid Ig production of all classes and subclasses, with the exception of IgA and IgG2b, with
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L2143-25MG | 04061833272091 |
| L2143-100MG | 04061833272077 |
| L2143-10MG | 04061833949849 |