H3878
猪去氧胆酸
≥98%, Bile acid
别名:
3α,6α-二羟基-5β-胆烷酸
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关于此项目
经验公式（希尔记法）:
C24H40O4
化学文摘社编号:
分子量:
392.57
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
201-483-2
MDL number:
Assay:
≥98%
Quality level:
产品名称
猪去氧胆酸, ≥98%
Quality Level
assay
≥98%
mp
200-201 °C (lit.)
SMILES string
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
InChI key
DGABKXLVXPYZII-SIBKNCMHSA-N
Gene Information
human ... NR1H2(7376), NR1H3(10062)
General description
异去氧胆酸是天然存在的次级胆汁酸。它通过小肠中的肠道菌群产生。在大鼠中，异去氧胆酸在胆汁的肠肝循环过程中由鹅去氧胆酸获得。
Application
异去氧胆酸已被用于：
- 作为液相色谱-质谱（LC-MS）联用法分析大鼠细胞中血清胆汁酸的标准品。
- 作为生长培养基的成分用于研究其作为抗衰老小分子对pex5Δ (Δ) 菌株时序寿命 (CLS) 的影响。
- 作为分析小鼠细胞中胆汁酸组成和总胆汁酸的成分。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Hang Zeng et al.
British journal of pharmacology, 174(8), 672-688 (2017-01-28)
Currently, ursodeoxycholic acid and obeticholic acid are the only two FDA-approved drugs for cholestatic liver diseases. Thus, new therapeutic approaches need to be developed. Here we have evaluated the anti-cholestasis effects of Schisandrol B (SolB), a bioactive compound isolated from
Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice
Pierre J F, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 311(2), G286-G304 (2016)
Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition
Cepa S, et al.
Toxicology and Applied Pharmacology, 338(9), 204-213 (2018)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H3878-5G | 04061832856612 |