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Merck
CN

H1753

肼屈嗪 盐酸盐

synthetic (organic), ≥99% (TLC), DNA methyltransferase inhibitor, powder

别名:

1-肼基二氮杂萘 盐酸盐

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关于此项目

经验公式（希尔记法）:
C8H8N4 · HCl
化学文摘社编号:
304-20-1
分子量:
196.64
NACRES:
NA.77
PubChem Substance ID:
24278461
UNSPSC Code:
12352200
EC Number:
206-151-0
MDL number:
MFCD00135998

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产品名称

肼屈嗪 盐酸盐,

InChI key

SECXUXOCDLQOBI-MKFZHGHUSA-N

InChI

1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;

SMILES string

Cl[H].N\N=C1/N=NC=C2C=CC=CC12

biological source

synthetic (organic)

assay

≥99% (TLC)

form

powder

mp

273 °C

solubility

water: 50 mg/mL

Quality Level

100

Gene Information

human ... MAOA(4128), MAOB(4129)

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相关类别

Application

盐酸肼屈嗪已用于：
  • 研究其作为血管扩张药，对大鼠幼鼠T细胞频率升高相关高血压的影响
  • 研究其作为氨基脲敏感性胺氧化酶(SSAO)抑制剂，对心肌缺血再灌注(I/R)损伤的影响
  • 研究其作为血管扩张药，对胰岛素分泌和葡萄糖耐受的影响

Biochem/physiol Actions

抑制DNA甲基转移酶并调节基因表达的表观遗传调控。非选择性MAO-A/B抑制剂；降压药；氨基脲敏感性胺氧化酶抑制剂。
盐酸肼屈嗪(Hydralazine)可用于治疗心力衰竭和高血压。

Features and Benefits

该化合物收录于受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢》页面。想要浏览手册的其他页面， 请单击此处。

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCZ0814
MKCT3552
MKCQ8899
MKCR9220
MKCQ2237

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Diabetes, 64(4), 1273-1283 (2014-10-30)
Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin
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Gut microbes, 16(1), 2390164-2390164 (2024-08-18)
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health concern, lacking specific therapeutic strategies. Time-restricted feeding (TRF) regimen demonstrated beneficial effects in NAFLD; however, the underlying mechanisms remain unclear. In this study, we established a NAFLD mouse model
Urmila P Kodavanti et al.
Toxicology and applied pharmacology, 268(2), 232-240 (2013-02-19)
Exposure to diesel exhaust (DE) and associated gases is linked to cardiovascular impairments; however, the susceptibility of hypertensive individuals is poorly understood. The objectives of this study were (1) to determine cardiopulmonary effects of gas-phase versus whole-DE and (2) to
Waste tea residue as a low cost adsorbent for removal of hydralazine hydrochloride pharmaceutical pollutant from aqueous media: An environmental remediation
Patil C S, et al.
Journal of Cleaner Production, 206, 407-418 (2019)
Dirk Westermann et al.
Basic research in cardiology, 107(6), 308-308 (2012-11-03)
Sildenafil inhibits cyclic GMP-specific phosphodiesterase type-5A (PDE5A) and can prevent cardiac hypertrophy and left ventricular (LV) dysfunction in mice subjected to severe pressure-overload. The pathophysiological role of sildenafil in adverse remodeling in the hypertensive heart after chronic renin-angiotensin aldosterone system
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