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Merck
CN

H1753

肼屈嗪 盐酸盐

synthetic (organic), ≥99% (TLC), DNA methyltransferase inhibitor, powder

别名:

1-肼基二氮杂萘 盐酸盐

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关于此项目

经验公式（希尔记法）:
C8H8N4 · HCl
化学文摘社编号:
304-20-1
分子量:
196.64
NACRES:
NA.77
PubChem Substance ID:
24278461
UNSPSC Code:
12352200
EC Number:
206-151-0
MDL number:
MFCD00135998

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产品名称

肼屈嗪 盐酸盐,

InChI key

SECXUXOCDLQOBI-MKFZHGHUSA-N

InChI

1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;

SMILES string

Cl[H].N\N=C1/N=NC=C2C=CC=CC12

biological source

synthetic (organic)

assay

≥99% (TLC)

form

powder

mp

273 °C

solubility

water: 50 mg/mL

Quality Level

100

Gene Information

human ... MAOA(4128), MAOB(4129)

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相关类别

Application

盐酸肼屈嗪已用于：
  • 研究其作为血管扩张药，对大鼠幼鼠T细胞频率升高相关高血压的影响
  • 研究其作为氨基脲敏感性胺氧化酶(SSAO)抑制剂，对心肌缺血再灌注(I/R)损伤的影响
  • 研究其作为血管扩张药，对胰岛素分泌和葡萄糖耐受的影响

Biochem/physiol Actions

抑制DNA甲基转移酶并调节基因表达的表观遗传调控。非选择性MAO-A/B抑制剂；降压药；氨基脲敏感性胺氧化酶抑制剂。
盐酸肼屈嗪(Hydralazine)可用于治疗心力衰竭和高血压。

Features and Benefits

该化合物收录于受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢》页面。想要浏览手册的其他页面， 请单击此处。

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCZ0814
MKCT3552
MKCQ8899
MKCR9220
MKCQ2237

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Waste tea residue as a low cost adsorbent for removal of hydralazine hydrochloride pharmaceutical pollutant from aqueous media: An environmental remediation
Patil C S, et al.
Journal of Cleaner Production, 206, 407-418 (2019)
Edmond A Rogers et al.
Scientific reports, 12(1), 11838-11838 (2022-07-14)
While clinical observations have confirmed a link between the development of neurodegenerative diseases and traumatic brain injuries (TBI), there are currently no treatments available and the underlying mechanisms remain elusive. In response, we have developed an in vitro pendulum trauma
Ruijia Feng et al.
Gut microbes, 16(1), 2390164-2390164 (2024-08-18)
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health concern, lacking specific therapeutic strategies. Time-restricted feeding (TRF) regimen demonstrated beneficial effects in NAFLD; however, the underlying mechanisms remain unclear. In this study, we established a NAFLD mouse model
Nadine S Sauter et al.
Diabetes, 64(4), 1273-1283 (2014-10-30)
Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin
Ashley D Hunt et al.
The Journal of organic chemistry, 78(17), 8847-8852 (2013-07-31)
Azomethine imines can be accessed upon heating appropriate alkynylhydrazide precursors. This simple thermal hydroamination approach allows the formation of five- and six-membered dipoles in modest to excellent yields. The structure of the acyl group is important to minimize side reactions
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