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C5851

Sigma-Aldrich

CGP 35348 水合物

≥97% (NMR), solid

别名:

(3-氨基丙基)(二乙氧基甲基)次膦酸 水合物

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About This Item

经验公式（希尔记法）:
C8H20NO4P · xH2O
CAS号:
123690-79-9
分子量:
225.22 (anhydrous basis)
MDL编号:
MFCD11045877
UNSPSC代码:
12352200
PubChem化学物质编号:
329775103
NACRES:
NA.77

方案

≥97% (NMR)

表单

solid

储存条件

desiccated

颜色

white

溶解性

H2O: >20 mg/mL

创始人

Novartis

储存温度

−20°C

SMILES字符串

O.CCOC(OCC)P(O)(=O)CCCN

InChI

1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2

InChI key

SRBHGEXMDCJOMS-UHFFFAOYSA-N

应用

CGP 35348水合物已用作γ-氨基丁酸-B (GABAB)受体抑制剂：
  • 用于研究其对大鼠海马体内源光信号(IOS)的影响[1]
  • 通过单独使用或与水杨酸钠联用，研究其对大鼠背皮层听觉反应的影响[2]
  • 研究其对肝细胞癌细胞(HCC)的影响[3]

生化/生理作用

CGP 35348是一种γ-氨基丁酸-B (GABAB)受体拮抗剂。它可穿过血脑屏障，对突触后受体的亲和性比突触前受体更高。[4]

特点和优势

《受体分类和信号转导》手册的 GABAB受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物是由 Novartis开发。浏览其他医药开发的化合物和已批准的药物/候选药物清单，请点击此处。
该化合物是神经科学研究推荐产品。点击此处 ，查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

注意

产品具有吸湿性

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000342607
    0000342606
    0000335779
    0000342607
    0000342606

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    Wouter Koek et al.
    The Journal of pharmacology and experimental therapeutics, 330(3), 876-883 (2009-07-01)
    Gamma-hydroxybutyrate (GHB) is used therapeutically and recreationally. The mechanism by which GHB produces its therapeutic and recreational effects is not entirely clear, although GABA(B) receptors seem to play an important role. This role could be complex, because there are indications
    Madhu P Sirivelu et al.
    Brain research, 1248, 107-114 (2008-11-19)
    Interleukin-1beta (IL-1beta), a cytokine that is closely associated with inflammation and immune stress, is known to interfere with reproductive functions. Earlier studies have demonstrated that IL-1beta inhibits the luteinizing hormone (LH) surge during the afternoon of proestrus in female rats.
    Fulvia Bongianni et al.
    Brain research, 1344, 134-147 (2010-05-21)
    The respiratory role of GABA(A), GABA(B) and glycine receptors within the Bötzinger complex (BötC) and the pre-Bötzinger complex (preBötC) was investigated in alpha-chloralose-urethane anesthetized, vagotomized, paralysed and artificially ventilated rabbits by using bilateral microinjections (30-50 nl) of GABA and glycine
    Abigail J Houston et al.
    European journal of pharmacology, 674(2-3), 327-331 (2011-12-07)
    The effects of subcutaneous (s.c.) administration of the GABA(B) receptor agonist baclofen were investigated on primary drinking in rats. Baclofen (1-4 mg/kg) produced a dose-related reduction in cumulative water intake in 16 h water-deprived rats during the 120 min measurement
    Chirag R Patel et al.
    Frontiers in neurology, 5, 235-235 (2014-12-03)
    Sodium salicylate (SS) is a widely used medication with side effects on hearing. In order to understand these side effects, we recorded sound-driven local-field potentials in a neural structure, the dorsal cortex of the inferior colliculus (ICd). Using a microiontophoretic
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