A3401
Ala-Ala-Phe-7-氨基-4-甲基香豆素
protease substrate
别名:
H-Ala-Ala-Phe-AMC
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关于此项目
经验公式（希尔记法）:
C25H28N4O5
化学文摘社编号:
分子量:
464.51
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
Quality Level
assay
≥98% (TLC)
form
powder
solubility
ethanol: 20 mg/mL, clear, colorless to light yellow
storage temp.
2-8°C
SMILES string
CC(N)C(=O)NC(C)C(=O)NC(Cc1ccccc1)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
InChI
1S/C25H28N4O5/c1-14-11-22(30)34-21-13-18(9-10-19(14)21)28-25(33)20(12-17-7-5-4-6-8-17)29-24(32)16(3)27-23(31)15(2)26/h4-11,13,15-16,20H,12,26H2,1-3H3,(H,27,31)(H,28,33)(H,29,32)
InChI key
FVRLYIFIDKXFHU-UHFFFAOYSA-N
General description
丙氨酸-丙氨酸-苯丙氨酸-7-酰胺基-4-甲基香豆素是蛋白水解活性的荧光底物。是带正电荷的底物分子。
糜蛋白酶和三肽基肽酶 ii 的底物。
Application
丙氨酸-丙氨酸-苯丙氨酸-7-酰胺基-4-甲基香豆素已被用于：
- 酶促反应混合液的制备
- 启动三肽基肽酶-1 (TPP1) 酶活性测定中的酶反应
- 启动溶酶体水解酶活性测定中的测定反应
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.
Effect of interfacial properties on the activation volume of adsorbed enzymes
Schuabb V, et al.
Colloids and Surfaces. B, Biointerfaces, 140, 497-504 (2016)
Accumulation of polyubiquitylated proteins in response to Ala-Ala-Phe-chloromethylketone is independent of the inhibition of tripeptidyl peptidase II
Villasevil E M, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1803(9), 1094-1105 (2010)
Sudipta Chakrabarti et al.
Neurobiology of disease, 127, 362-373 (2019-04-01)
The late-infantile Batten disease or late-infantile neuronal ceroid lipofuscinosis (LINCL) is an autosomal recessive lysosomal storage disorder caused by mutations in the Cln2 gene leading to deficiency of lysosomal enzyme tripeptidyl peptidase 1 (TPP1). At present, available options for this
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A3401-25MG | 04061832904146 |