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方案
≥85% (HPLC)
表单
solid
储存温度
−20°C
生化/生理作用
Colupulone is a bitter acid extracted from HOPS which activates transcription of xenobiotic metabolism via the human nuclear pregnane X receptor.
Mixture of predominantly colupulone and lupulone is an activator of the extrinsic apoptotic pathway via TRAIL DR4/DR5 death receptors and antimicrobial agent.
分析说明
predominantly colupulone and lupulone
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Steven A Kliewer et al.
Endocrine reviews, 23(5), 687-702 (2002-10-10)
The nuclear pregnane X receptor (PXR; NR1I2) is an important component of the body's adaptive defense mechanism against toxic substances including foreign chemicals (xenobiotics). PXR is activated by a large number of endogenous and exogenous chemicals including steroids, antibiotics, antimycotics
Denise G Teotico et al.
Molecular pharmacology, 74(6), 1512-1520 (2008-09-05)
Hops extracts are used to alleviate menopausal symptoms and as an alternative to hormone replacement therapy, but they can produce potentially harmful drug-drug interactions. The nuclear xenobiotic receptor pregnane X receptor (PXR) is promiscuously activated by a range of structurally
Steven A Kliewer et al.
Journal of lipid research, 43(3), 359-364 (2002-03-15)
The nuclear pregnane X receptor (PXR; NR1I2) is an integral component of the body's defense mechanism against chemical insult (chemoprotection). PXR is activated by a diverse array of lipophilic chemicals, including xenobiotics and endogenous substances, and regulates the expression of
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