质量水平
产品线
BioUltra
形式
flakes
分子量
Mr ~16000-24000
杂质
insoluble matter:, passes filter test
≤0.001% peroxides (as H2O2):
pH值(酸碱度)
5.5-7.0 (25 °C, 50 mg/mL in H2O)
mp
63-66 °C
溶解性
H2O: 50 mg/mL at 25 °C, clear, colorless
痕量阴离子
chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg
痕量阳离子
Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤200 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg
λ
50 mg/mL in H2O
紫外吸收
λ: 260 nm Amax: 0.15
λ: 280 nm Amax: 0.20
SMILES字符串
C(CO)O
InChI
1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
InChI key
LYCAIKOWRPUZTN-UHFFFAOYSA-N
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一般描述
聚乙二醇(PEG)是一种聚醚化合物,用于作为化妆品,药品及食品的添加剂。它包含重复的乙二醇[-(CH2CH2O)n]单元。
应用
聚乙二醇被用于水分散体系中的非吸附性高分子或作为活性自组装凝胶通过排空相互作用刺激纤维束的形成。
生化/生理作用
聚乙二醇(PEG)是一种合成高分子,被用作生物偶联和纳米药物延长血液循环时间,提高药物疗效的金标准。PEG-偶联药物被认为可在人体上安全使用,并得到美国食品和药品监督局(FDA)批准。PEG在许多生物医学应用,包括生物传感器,成像和组织工程。它还排斥蛋白质吸附和降低肝脏摄取,这有助于包裹纳米颗粒。
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Science advances, 4(4), eaao1470-eaao1470 (2018-05-10)
The formation of emulsions from multiple immiscible fluids is governed by classical concepts such as surface tension, differential chemical affinity and viscosity, and the action of surface-active agents. Much less is known about emulsification when one of the components is
Polymers, 12(2) (2020-02-07)
Poly(ethylene glycol) (PEG) is widely used as a gold standard in bioconjugation and nanomedicine to prolong blood circulation time and improve drug efficacy. The conjugation of PEG to proteins, peptides, oligonucleotides (DNA, small interfering RNA (siRNA), microRNA (miRNA)) and nanoparticles
Expert opinion on drug delivery, 13(9), 1257-1275 (2016-04-28)
Polyethylene glycol (PEG) is a polymer of choice in drug delivery systems. This USFDA-approved polymer is popular due to its tunable properties and well-established safety profile: prime requisites considered during the selection of any excipient in formulation development. The unique
Biomacromolecules, 21(6), 2320-2333 (2020-04-29)
Phosphorylcholine is known to repel the absorption of proteins onto surfaces, which can prevent the formation of a protein corona on the surface of nanoparticles. This can influence the fate of nanoparticles used for drug delivery. This material could therefore
Proceedings of the National Academy of Sciences of the United States of America, 113(20), 5498-5502 (2016-05-04)
Living cells sense the mechanical features of their environment and adapt to it by actively remodeling their peripheral network of filamentary proteins, known as cortical cytoskeleton. By mimicking this principle, we demonstrate an effective control strategy for a microtubule-based active
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