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安全信息

94261

Sigma-Aldrich

LL-37 (human) trifluoroacetate salt

≥95% (HPLC)

别名:

Human LL-37 amide Trifluoroacetate

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About This Item

经验公式(希尔记法):
C205H341N61O52 · xC2HF3O2
分子量:
4492.28 (free base basis)
UNSPSC代码:
51101500
NACRES:
NA.85

质量水平

方案

≥95% (HPLC)

表单

powder (Lyophilisate)

颜色

colorless to white

溶解性

H2O: 1 mg/mL, clear, colorless

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
viruses

作用机制

cell membrane | interferes

储存温度

−20°C

Amino Acid Sequence

Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-NH2

一般描述

Chemical structure: peptide

应用

LL-37 is used to study host defense mechanisms.

生化/生理作用

LL-37 is a muntifunctional host defense peptide with antibacterial, antiviral, and immunomodulating activities. It is the only cathelicidin-type peptide found in human. In addition to its antimicrobial activities, LL-37 has been found to regulate inflammation and neutralize lipopolysaccharides from Gram-negative bacteria.

包装

1mg

其他说明

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Keep in a dry place.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number

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Ainhoa Revilla-Guarinos et al.
Applied and environmental microbiology, 86(14) (2020-05-18)
Bce-like systems mediate resistance against antimicrobial peptides in Firmicutes bacteria. Lactobacillus casei BL23 encodes an "orphan" ABC transporter that, based on homology to BceAB-like systems, was proposed to contribute to antimicrobial peptide resistance. A mutant lacking the permease subunit was

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