一般描述
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Human Renal Proximal Tubular Epithelial Cells (HRPTEpC) provide a useful tool for studying various aspects of pathology and biology of the human renal proximal tubular cells in vitro. HRPTEpC have recently been used in a study of metabolic enzymes responding to energy depletion in renal cells. HRPTEpCs have a pivotal role in kidney function including reabsorbtion of glucose and protein, and also play a part in the glucotoxicity associated with diabetes.
Human Renal Proximal Tubular Epithelial Cells (HRPTEpC) provide a useful tool for studying various aspects of pathology and biology of the human renal proximal tubular cells in vitro. HRPTEpC have recently been used in a study of metabolic enzymes responding to energy depletion in renal cells. HRPTEpCs have a pivotal role in kidney function including reabsorbtion of glucose and protein, and also play a part in the glucotoxicity associated with diabetes.
细胞系来源
Kidney
应用
Kidney disease, diabetes, glucotoxicity, pathology. kidney function, reabsorbtion of glucose and protein, biology of renal proximal tubular cells in vitro, metabolic enzymes, cell energy usage.
包装
First or second passage, >500,000 cells in RenaEpi Basal Medium containing 10% FBS & 10% DMSO.
组分
RenaEpi Basal Medium containing 10% FBS & 10% DMSO
质量
Each lot was tested for proper morphology, ability to attach and spread on tissue culture ware surface, and proliferate in RenaEpi Growth Medium, Negative for HIV, Hepatitis B, Hepatitis C, mycoplasma, bacteria, and fungi.
其他说明
Can be cultured at least 6 population doublings
免责声明
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Fatimah K Khalaf et al.
Journal of the American Heart Association, 9(3), e013933-e013933 (2020-02-06)
Background Recent studies have highlighted a critical role for a group of natriuretic hormones, cardiotonic steroid (CTS), in mediating renal inflammation and fibrosis associated with volume expanded settings, such as chronic kidney disease. Immune cell adhesion is a critical step
Duygu Elif Yilmaz et al.
The Journal of biological chemistry, 298(3), 101589-101589 (2022-01-17)
Current immunosuppressive strategies in organ transplantation rely on calcineurin inhibitors cyclosporine A (CsA) or tacrolimus (Tac). Both drugs are nephrotoxic, but CsA has been associated with greater renal damage than Tac. CsA inhibits calcineurin by forming complexes with cyclophilins, whose
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