92243
胆固醇 N-（2-二甲基氨基乙基）氨基甲酸酯
≥98% (TLC)
别名:
3β-{N-[2-(二甲氨基)乙基]氨基甲酰基}膽固醇, DC-Chol
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C32H56N2O2
化学文摘社编号:
分子量:
500.80
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.85
产品名称
胆固醇 N-（2-二甲基氨基乙基）氨基甲酸酯, ≥98% (TLC)
SMILES string
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCN(C)C
InChI
1S/C32H56N2O2/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35)/t23-,25?,26+,27-,28+,29+,31+,32-/m1/s1
InChI key
HIHOWBSBBDRPDW-MTIZRNOUSA-N
assay
≥98% (TLC)
form
powder or crystals
functional group
ester
storage temp.
−20°C
Quality Level
Application
- 白细胞介素6在阳离子脂质体诱导抗原特异性粘膜免疫球蛋白A中的作用。：本研究探讨了在阳离子脂质体中使用胆固醇N-(2-二甲基氨基乙基)氨基甲酸酯促进粘膜免疫球蛋白A的产生，突出了其在疫苗开发中的潜力（Tada et al., 2021）。
- 鼻腔联合接种肺炎球菌表面蛋白A以及DOTAP和DC-chol组成的阳离子脂质体，可使小鼠获得抗原介导的抗肺炎链球菌感染的保护性免疫。：这项研究证实了胆固醇N-(2-二甲基氨基乙基)氨基甲酸酯在鼻腔疫苗中的效力，为预防呼吸道感染提供了一种有前景的策略（Tada et al., 2018）。
Biochem/physiol Actions
阳离子脂质体，在癌症基因治疗中进行研究，作为疫苗递送系统/佐剂。
Packaging
无底玻璃瓶。内含物装在锥底内插管中。
hcodes
Hazard Classifications
Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Xin-Long Ma et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 93, 238-244 (2017-06-24)
This study aimed at exploring the effect of microRNA-129-5p (miR-129-5p) targeting high mobility group box-1 (HMGB1)-receptor for advanced glycation end-products (RAGE) signaling pathway on the revascularization in a collagenase-induced intracerebral hemorrhage (ICH) rat model. OX26-pGFAP-IL, an immunoliposome expressing miR-129-5p was
Mónica Muñoz-Ubeda et al.
Biomacromolecules, 11(12), 3332-3340 (2010-11-10)
Lipoplexes constituted by calf-thymus DNA (CT-DNA) and mixed cationic liposomes consisting of varying proportions of the cationic lipid 3β-[N-(N',N'-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride (DC-Chol) and the zwitterionic lipid, 1,2-dioleoyl-sn-glycero-3-phosphoetanolamine (DOPE) have been analyzed by means of electrophoretic mobility, SAXS, and fluorescence anisotropy experiments
Zhenyu Zhong et al.
Nature communications, 4, 1611-1611 (2013-03-21)
Exposure to particulate crystals can induce oxidative stress in phagocytes, which triggers NLRP3 inflammasome-mediated interleukin-1β secretion to initiate undesirable inflammatory responses that are associated with both autoinflammatory and metabolic diseases. Although mitochondrial reactive oxygen species have a central role in
Nagavendra Kommineni et al.
Pharmaceutics, 11(3) (2019-04-03)
Jevtana® is a micellar cabazitaxel (CBZ) solution that was approved for prostate cancer in 2010, and recently, this drug has been reported for breast cancer. The purpose of this study is to evaluate the mediated delivery of CBZ via liposomes
Rui Tada et al.
Molecular pharmaceutics, 15(9), 4226-4234 (2018-08-16)
Infections remain a major threat to human lives. To overcome the threat caused by pathogens, mucosal vaccines are considered a promising strategy. However, no inactivated and/or subunit mucosal vaccine has been approved for human use, largely because of the lack
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持