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Merck
CN

90190

Transferrin from human blood plasma

≥95% (GE)

别名:

Human transferrin, Siderophilin

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化学文摘社编号:
UNSPSC Code:
12352202
EC Number:
234-318-8
NACRES:
NA.61
MDL number:
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产品名称

Transferrin from human blood plasma, ≥95% (GE)

biological source

human plasma

assay

≥95% (GE)

form

powder or crystals

mol wt

Mr ~79550

technique(s)

tissue culture: suitable

impurities

≤0.01% iron traces (AAS)

solubility

H2O: 50 mg/mL, clear, colorless to faintly yellow or pink

UniProt accession no.

storage temp.

2-8°C

Quality Level

Gene Information

human ... TF(7018)

Application

Transferrin is an important supplement in serum-free tissue culture media.

Biochem/physiol Actions

Transferrin is glycoprotein, approx. 80 kDa, with two binding sites for iron. It transports iron from its primary store in the liver to tissues that require iron, primarily bone marrow and spleen, but also brain. It binds Fe3+ extremely tightly (Kdiss 10-30 to 10-27), protecting against oxidant effects of free plasma iron.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Other Notes

Review: Iron transport and storage

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

高风险级别生物产品--人源产品
高风险级别生物产品--人源产品
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B. Gorinsky
Adv. Red Blood Cell Biol., D.J. Weatherall et al., eds., 7-7 (1981)
U R Goonetilleke et al.
mBio, 3(2) (2012-03-15)
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Iron transport and storage.
R R Crichton et al.
European journal of biochemistry, 164(3), 485-506 (1987-05-04)
Melissa Pynnonen et al.
PLoS pathogens, 7(7), e1002104-e1002104 (2011-07-14)
Staphylococcus aureus nasal colonization is an important risk factor for community and nosocomial infection. Despite the importance of S. aureus to human health, molecular mechanisms and host factors influencing nasal colonization are not well understood. To identify host factors contributing
Jieru E Lin et al.
Cancer research, 76(2), 339-346 (2016-01-17)
Obesity is a well-known risk factor for colorectal cancer but precisely how it influences risks of malignancy remains unclear. During colon cancer development in humans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that occurs

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