90182
Nα-甲苯磺酰基- L -赖氨酸氯甲基酮 盐酸盐
≥99.0% (AT)
别名:
(3S)-1-氯-3-甲苯磺酰氨基-7-氨基-2-庚酮 盐酸盐, (3S)-7-氨基-1-氯-3-甲苯磺酰氨基-2-庚酮 盐酸盐, TLCK, 甲苯磺酰基- L -赖氨酰-氯甲烷 盐酸盐
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关于此项目
经验公式（希尔记法）:
C14H21ClN2O3S · HCl
化学文摘社编号:
分子量:
369.31
MDL number:
Beilstein/REAXYS Number:
7106867
NACRES:
NA.77
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352202
EC Number:
224-266-4
产品名称
Nα-甲苯磺酰基- L -赖氨酸氯甲基酮 盐酸盐, ≥99.0% (AT)
InChI key
YFCUZWYIPBUQBD-ZOWNYOTGSA-N
InChI
1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1
SMILES string
Cl[H].Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl
biological source
synthetic
assay
≥99.0% (AT)
form
powder or crystals
optical activity
[α]20/D −7.8±0.5°, c = 2% in H2O
storage temp.
−20°C
Quality Level
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Other Notes
一种可能与酶活性位点上的组氨酸或半胱氨酸残基反应的烷基化试剂。灭活丝氨酸蛋白酶，如胰蛋白酶 和梭菌蛋白酶 。糜蛋白酶不受影响。为了防止蛋白水解降解，TLCK 和 TPCK 的组合可用于整个蛋白的分离过程，如分离组蛋白。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Further observations on substrate-derived chloromethyl ketones that inactivate trypsin.
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The objective of this study was to ascertain the mechanism by which serine and cysteine proteinase inhibitors interfere with production of NO by LPS-activated rat alveolar macrophages. Macrophages were incubated in the presence of LPS+ test agent for 24 hr.
Studies on the active site of clostripain. The specific inactivation by the chloromethyl ketone derived from -N-tosyl-L-lysine.
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The Journal of biological chemistry, 246(24), 7675-7682 (1971-12-25)
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Chicken erythrocyte histones 2A, 2B, and 3 can be resolved into nonallelic primary structure variants by polyacrylamide gel electrophoresis in the presence of Triton X-100. These variants were isolated and characterized by analysis of their tryptic and thermolytic peptides. The
I Kourteva et al.
Analytical biochemistry, 162(2), 345-349 (1987-05-01)
A technique for quickly detecting nanogram quantities of low- and high-molecular-weight inhibitors of some serine proteases is described. The inhibitor solutions are spotted onto agar films which contain either L-1-p-tosylamino-2-phenylethyl chloromethyl ketone (TPCK)-trypsin or tosyl lysine chloromethyl ketone (TLCK)-chymotrypsin. Enzyme
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