90182
Nα-甲苯磺酰基- L -赖氨酸氯甲基酮 盐酸盐
≥99.0% (AT)
别名:
(3S)-1-氯-3-甲苯磺酰氨基-7-氨基-2-庚酮 盐酸盐, (3S)-7-氨基-1-氯-3-甲苯磺酰氨基-2-庚酮 盐酸盐, TLCK, 甲苯磺酰基- L -赖氨酰-氯甲烷 盐酸盐
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所有图片(1)
About This Item
经验公式（希尔记法）:
C14H21ClN2O3S · HCl
CAS号:
分子量:
369.31
Beilstein:
7106867
EC 号:
MDL编号:
UNSPSC代码:
12352202
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
生物来源
synthetic
质量水平
方案
≥99.0% (AT)
表单
powder or crystals
旋光性
[α]20/D −7.8±0.5°, c = 2% in H2O
储存温度
−20°C
SMILES字符串
Cl[H].Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl
InChI
1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1
InChI key
YFCUZWYIPBUQBD-ZOWNYOTGSA-N
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其他说明
一种可能与酶活性位点上的组氨酸或半胱氨酸残基反应的烷基化试剂。灭活丝氨酸蛋白酶，如胰蛋白酶 和梭菌蛋白酶 。糜蛋白酶不受影响。为了防止蛋白水解降解，TLCK 和 TPCK 的组合可用于整个蛋白的分离过程，如分离组蛋白。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Further observations on substrate-derived chloromethyl ketones that inactivate trypsin.
E Shaw et al.
Archives of biochemistry and biophysics, 139(2), 298-305 (1970-08-01)
J M Griscavage et al.
Biochemical and biophysical research communications, 215(2), 721-729 (1995-10-13)
The objective of this study was to ascertain the mechanism by which serine and cysteine proteinase inhibitors interfere with production of NO by LPS-activated rat alveolar macrophages. Macrophages were incubated in the presence of LPS+ test agent for 24 hr.
Studies on the active site of clostripain. The specific inactivation by the chloromethyl ketone derived from -N-tosyl-L-lysine.
W H Porter et al.
The Journal of biological chemistry, 246(24), 7675-7682 (1971-12-25)
M K Urban et al.
Biochemistry, 18(18), 3952-3960 (1979-09-04)
Chicken erythrocyte histones 2A, 2B, and 3 can be resolved into nonallelic primary structure variants by polyacrylamide gel electrophoresis in the presence of Triton X-100. These variants were isolated and characterized by analysis of their tryptic and thermolytic peptides. The
I Kourteva et al.
Analytical biochemistry, 162(2), 345-349 (1987-05-01)
A technique for quickly detecting nanogram quantities of low- and high-molecular-weight inhibitors of some serine proteases is described. The inhibitor solutions are spotted onto agar films which contain either L-1-p-tosylamino-2-phenylethyl chloromethyl ketone (TPCK)-trypsin or tosyl lysine chloromethyl ketone (TLCK)-chymotrypsin. Enzyme
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