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方案
≥98% (TLC)
表单
powder with small lumps
旋光性
[α]/D +25.0±1.0°, c = 1 in 1 M HCl
组成
carbon, 54.1-55.7%
nitrogen, 10.4-11.0%
技术
ligand binding assay: suitable
颜色
white
SMILES字符串
CN[C@@H](C(C)C)C(O)=O
InChI
1S/C6H13NO2/c1-4(2)5(7-3)6(8)9/h4-5,7H,1-3H3,(H,8,9)/t5-/m0/s1
InChI key
AKCRVYNORCOYQT-YFKPBYRVSA-N
生化/生理作用
N-Methyl amino acids play an important role in investigations on prevention or therapy of Alzheimer′s disease, neurofibrillary tangles or amyloid plaque are physiological characteristics of this disease and ?-amyloid(40) fibrillogenesis and disassembly of ?-amyloid(40) fibrils is inhibited by short ?-amyloid congeners containing N-methyl amino acids at alternate residue.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Eye Dam. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex.
David R Calabrese et al.
Nature communications, 9(1), 4229-4229 (2018-10-14)
G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between different G4 structures are rare. Here, we
Franco Cataldo et al.
Life (Basel, Switzerland), 3(3), 449-473 (2013-01-01)
A series of non-proteinogenic amino acids, most of them found quite commonly in the meteorites known as carbonaceous chondrites, were subjected to solid state radiolysis in vacuum to a total radiation dose of 3.2 MGy corresponding to 23% of the
D J Gordon et al.
Biochemistry, 40(28), 8237-8245 (2001-07-11)
A potential goal in the prevention or therapy of Alzheimer's disease is to decrease or eliminate neuritic plaques composed of fibrillar beta-amyloid (Abeta). In this paper we describe N-methyl amino acid containing congeners of the hydrophobic "core domain" of Abeta
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