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Merck
CN

89870

Sigma-Aldrich

甲苯-2,4-二异氰酸酯

purum, suitable for electron microscopy, ≥98.0% (GC)

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别名:
2,4-二异氰酸基甲苯, 2,4-二异氰酸甲苯酯, 4-甲基-间亚苯基二异氰酸酯
经验公式(希尔记法):
C9H6N2O2
CAS号:
分子量:
174.16
Beilstein:
744602
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.25

等级

purum

质量水平

检测方案

≥98.0% (GC)

形式

liquid

技术

electron microscopy: suitable

折射率

n20/D 1.567

bp

124-126 °C/18 mmHg (lit.)
251 °C (lit.)

mp

19.5-21.5 °C (lit.)

密度

1.21 g/mL at 20 °C
1.22 g/mL at 20 °C (lit.)

SMILES字符串

Cc1ccc(cc1N=C=O)N=C=O

InChI

1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3

InChI key

DVKJHBMWWAPEIU-UHFFFAOYSA-N

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应用

甲苯2,4-二异氰酸酯已被用于研究其职业危害(哮喘、皮炎)和相关作用机理。共价蛋白交联试剂;用于将抗体固定在RIA的塑料表面上

其他说明

共价蛋白交联试剂;用于将抗体固定在RIA的塑料表面上

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

危险分类

Acute Tox. 1 Inhalation - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 2

闪点(°F)

269.6 °F

闪点(°C)

132 °C

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

非剧毒-急性毒性1

分析证书(COA)

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T Saito et al.
Clinica chimica acta; international journal of clinical chemistry, 133(3), 301-310 (1983-10-14)
A novel procedure to fix antibody on a plastic surface was developed, using a polystyrene tube treated with 0.5% toluene 2,4-diisocyanate (TC) dissolved in carbon tetrachloride. Using 125I-labelled IgG, we found that the rate of immobilization of IgG was significantly
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Allergy, asthma & immunology research, 12(4), 608-625 (2020-05-14)
Accumulating evidence has suggested that toll-like receptor 4 (TLR4) is critically involved in the pathogenesis of asthma. The aim of this study was to investigate the role of TLR4 in toluene diisocyanate (TDI)-induced allergic airway inflammation. TLR4-/- and wild-type (WT)
[57] Bifunctional reagents.
F Wold
Methods in enzymology, 25, 623-651 (1972-01-01)
Rahul Purwar et al.
Experimental dermatology, 20(9), 709-714 (2011-05-17)
Keratinocytes synthesize complement component 3 (C3) constitutively, and increased expression of C3 has been described during skin inflammation. In this study, we investigated the role of C3 in T cell-mediated allergic contact dermatitis, which is a clinical manifestation of contact
Norman Mangner et al.
JACC. Cardiovascular imaging, 7(12), 1198-1205 (2014-10-13)
The aim of our study was to assess geometric and functional changes of the heart in obese compared with nonobese children and adolescents. Obesity in children and adolescents has increased over the past decades and is considered a strong risk

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