82415
Prunetin
≥98.0% (TLC)
别名:
4′,5-Dihydroxy-7-methoxyisoflavone
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关于此项目
经验公式（希尔记法）:
C16H12O5
化学文摘社编号:
分子量:
284.26
UNSPSC Code:
51111800
NACRES:
NA.77
PubChem Substance ID:
EC Number:
209-018-5
Beilstein/REAXYS Number:
292155
MDL number:
InChI key
KQMVAGISDHMXJJ-UHFFFAOYSA-N
InChI
1S/C16H12O5/c1-20-11-6-13(18)15-14(7-11)21-8-12(16(15)19)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3
SMILES string
COc1cc(O)c2C(=O)C(=COc2c1)c3ccc(O)cc3
assay
≥98.0% (TLC)
form
powder
Quality Level
Biochem/physiol Actions
Inhibitor of both cytoplasmic and mitochondrial human liver aldehyde dehydrogenases, possibly by binding at an allosteric site.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Tae-Gue Ahn et al.
Biochemical pharmacology, 85(10), 1525-1533 (2013-02-27)
Prunetin is an O-methylated isoflavone, which is a type of flavonoid. There are a limited number of reports detailing the biological activities of prunetin. Although an anti-inflammatory effect of prunetin has been reported in vitro, to our knowledge, there have
Jean-Philippe Antignac et al.
Rapid communications in mass spectrometry : RCM, 17(12), 1256-1264 (2003-06-18)
In an international context of promoting scientific research on food safety, the interest in molecules having potential hormonal disrupting effects is growing. While industrial endocrine disruptors (phthalates, alkylphenols, PCBs, etc.) have been studied for several years, natural compounds like phytoestrogens
Hyun Jae Lee et al.
Phytotherapy research : PTR, 25(8), 1196-1200 (2011-02-10)
This study investigated whether prunetin significantly affects the secretion, production and gene expression of mucin from cultured airway epithelial cells. Confluent primary rat tracheal surface epithelial (RTSE) cells were pretreated with adenosine triphosphate (ATP) for 5 min and then chased for
Stephen W J Wang et al.
The Journal of pharmacology and experimental therapeutics, 329(3), 1023-1031 (2009-03-07)
Flavonoids have poor bioavailabilities largely because of metabolism via UDP-glucuronosyltransferases (UGTs). This study aims to further understand the functions of UGT in metabolizing genistein and apigenin, two compounds metabolized more extensively in the gut than in the liver. Because Gunn
Soon-Sen Leow et al.
Experimental gerontology, 106, 198-221 (2018-03-20)
Palm fruit juice (PFJ) containing oil palm phenolics is obtained as a by-product from oil palm (Elaeis guineensis) fruit milling. It contains shikimic acid, soluble fibre and various phenolic acids including p-hydroxybenzoic acid and three caffeoylshikimic acid isomers. PFJ has
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