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80198

Sigma-Aldrich

吡咯喹啉醌酸 二钠盐

≥97.0% (HPLC)

别名:

PQQ, 吡咯喹啉醌 二钠盐

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About This Item

经验公式（希尔记法）:
C14H4N2Na2O8
CAS号:
122628-50-6
分子量:
374.17
MDL编号:
MFCD00151711
UNSPSC代码:
12352005
PubChem化学物质编号:
329768729
NACRES:
NA.79

生物来源

fermentation/recombinant

质量水平

100

方案

≥97.0% (HPLC)

表单

powder

颜色

red-brown to deep orange
 red-brown to deep red-brown

储存温度

2-8°C

SMILES字符串

OC(=O)c1cc(nc2C(=O)C(=O)c3cc([nH]c3-c12)C(=O)O[Na])C(=O)O[Na]

InChI

1S/C14H6N2O8.2Na/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18;;/h1-2,15H,(H,19,20)(H,21,22)(H,23,24);;/q;2*+1/p-2

InChI key

UFVBOGYDCJNLPM-UHFFFAOYSA-L

相关类别

一般描述

吡咯喹啉醌（PQQ）最常见于植物、少数几种细菌和单细胞真核生物（如酵母）。它主要从甲基营养型细菌中获取。PQQ也存在于哺乳动物组织中。

应用


  • 新型膳食吡咯并喹啉醌二钠盐（mnemoPQQ）的安全性评估：本研究考察了吡咯并喹啉醌的安全性，这对其在临床和诊断检测开发中的应用有一定影响。具体而言，它解决了膳食补充剂中所用化合物的问题，并可能涉及对安全性和毒性有最高要求的临床试验（Shiojima et al., 2022）。


生化/生理作用

在细菌中，吡咯喹啉醌（PQQ）用作氧化还原循环辅因子。它也可以作为辅因子（辅基）参与葡萄糖和甲醇脱氢酶的酶催化氧化还原反应。PQQ可在脂质体中用于建立简单的均相测定，从而通过抗微生物肽和合成共聚物对膜的通透化进行检测。在牛血浆胺氧化酶中，吡咯喹啉醌可作为辅因子。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCJ8330
BCCD8905
BCCB1989
BCBR8576V
BCBQ2450V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What solvents can be used to reconstitute Product 80198, Methoxatin?

    Product 80198, Methoxatin disodium salt is soluble in water up to 3 mg/ml. The following reference by Zimmerman, L.B. et al., Analytical Biochemistry, 411 (2), 194-199 (2011) has solubilized the product in 250 μM in HEPES buffer (20 mM, pH 7.0, 290 mOsmol/kg).

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Xiang-Hua Xiong et al.
International journal of molecular sciences, 12(12), 8913-8923 (2012-01-25)
Pyrroloquinoline quinone (PQQ) was produced by fermentation of the Methylovorus sp. MP688 strain and purified by ion-exchange chromatography, crystallization and recrystallization. The yield of PQQ reached approximately 125 mg/L and highly pure PQQ was obtained. To determine the optimum dose
Peilian Wei et al.
Preparative biochemistry & biotechnology, 47(7), 709-719 (2017-04-28)
Methylobacillus sp. zju323 was adopted to improve the biosynthesis of pyrroloquinoline quinone (PQQ) by systematic optimization of the fermentation medium. The Plackett-Burman design was implemented to screen for the key medium components for the PQQ production. CoCl
Absorbance-based assay for membrane disruption by antimicrobial peptides and synthetic copolymers using pyrroloquinoline quinone-loaded liposomes
Zimmerman LB, et al.
Analytical biochemistry, 411(2), 194-199 (2011)
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