78825
甘草素
≥97.0% (HPLC)
别名:
7,4′-二羟基黄酮, 7-羟基-2-（4-羟基苯基）-2,3-二氢-4 H -1-苯并吡喃-4-酮
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关于此项目
经验公式（希尔记法）:
C15H12O4
化学文摘社编号:
分子量:
256.25
UNSPSC Code:
12352202
NACRES:
NA.28
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
359378
产品名称
甘草素, ≥97.0% (HPLC)
InChI
1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1
SMILES string
Oc1ccc(cc1)[C@@H]2CC(=O)c3ccc(O)cc3O2
InChI key
FURUXTVZLHCCNA-AWEZNQCLSA-N
assay
≥97.0% (HPLC)
form
powder or crystals
impurities
≤7% water
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
Quality Level
Application
甘草素已：
- 用于研究其在结直肠癌治疗中对肿瘤转移的抑制作用
- 用作柴胡疏肝散(CSS)提取物超高效液相色谱(UPLC)的参比标准品
- 用作一种潜在的抗丙肝病毒(HCV)感染的抗病毒药物
Biochem/physiol Actions
甘草素具有抗糖尿病和抗胆汁的特性。它通过抑制活化B细胞核因子卡帕轻链增强子(NF-κB)依赖的诱导性NOS (iNOS)诱导，对Raw246.7细胞产生抗炎活性。甘草素可通过阻挡Hippo/Yes相关蛋白质并转化生长因子-β1 (TGF-β1)/小母抗Dpp (Smad)组分抑制肝纤维化形成。它是一种选择性雌激素受体β调节剂细胞。甘草素通过破坏线粒体膜电位和增加活性氧的产生而诱导SMM-721细胞凋亡。
General description
甘草素是一种黄酮类化合物和雌激素化合物，发现于甘草（甘草根）的根提取物和其他几种植物。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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After the Women's Health Initiative found that the risks of hormone therapy outweighed the benefits, a need for alternative drugs to treat menopausal symptoms has emerged. We explored the possibility that botanical agents used in Traditional Chinese Medicine for menopausal
Young Woo Kim et al.
American journal of physiology. Gastrointestinal and liver physiology, 296(2), G372-G381 (2008-12-17)
Liquiritigenin (LQ), an active component of licorice, has an inhibitory effect on LPS-induced inhibitory nitric oxide synthase expression. This study investigated the effects of LQ on choleresis, the expression of hepatic transporters and phase-II enzymes, and fulminant hepatitis. The choleretic
Eun-Ju Yang et al.
Neurotoxicology, 39, 114-123 (2013-09-10)
The progressive death of neurons following exposure to high concentrations of glutamate leads to loss of learning and memory and pathogenesis of neurodegenerative disorders. Therefore, identification of drugs that protect against glutamate-mediated neuronal cell death is a good strategy for
Suengmok Cho et al.
Bioorganic & medicinal chemistry, 20(11), 3493-3501 (2012-05-01)
Licorice (Glycyrrhiza glabra, GG) is one of the most frequently used herbal medicines worldwide, and its various biological activities have been widely studied. GG is reported to have neurological properties such as antidepressant, anxiolytic, and anticonvulsant effects. However, its hypnotic
Eun Mi Choi
International immunopharmacology, 12(1), 139-143 (2011-11-26)
Liquiritigenin is one of the flavonoids present in Glycyrrhizae radix. In the present study, the effects of liquiritigenin on the function of osteoblastic MC3T3-E1 cells were studied. Liquiritigenin caused a significant elevation of cell growth, alkaline phosphatase activity, collagen synthesis
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