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75447

Sigma-Aldrich

2-氧代己二酸 单钠盐

≥95.0% (HPLC)

别名:

α-酮己二酸 单钠盐, 2-己二酸, 2-氧己二酸 单钠盐

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About This Item

经验公式（希尔记法）:
C6H8O5
CAS号:
3184-35-8
分子量:
160.12
MDL编号:
MFCD00010004
UNSPSC代码:
12352106
PubChem化学物质编号:
329766428
NACRES:
NA.25

质量水平

100

方案

≥95.0% (HPLC)
≥97.0% (T)

表单

powder

脂质类型

saturated FAs

储存温度

2-8°C

SMILES字符串

OC(=O)CCCC(=O)C(O)=O

InChI

1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)

InChI key

FGSBNBBHOZHUBO-UHFFFAOYSA-N

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应用


  • 来自中间型高温放线菌用于生产新同型谷氨酸的苯丙氨酸脱氢酶的设计：展示了2-氧代己二酸在酶工程中的应用，增强了用于生产新型化合物的生物催化过程，这对制药和化学工业至关重要（Tariq et al., 2022）。

生化/生理作用

TCA循环和赖氨酸生物合成之间的重要代谢物。 对于线粒体代谢物转运蛋白具有意义。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319

危险分类

Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM3755
BCCG9094
BCBQ8969V
BCBH4492V
1398444V

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D G Hine et al.
Biomedical mass spectrometry, 11(7), 332-339 (1984-07-01)
Numerous abnormal metabolites were identified in large amounts in the urine of hypoglycin-treated rats using capillary gas chromatography/mass spectrometry-computer analysis. These metabolites are not detectable in significant amounts in normal rats' urine. Ten of them have not been previously associated
A fatal case of 2-keto-, 2-hydroxy- and 2-aminoadipic aciduria: relation of organic aciduria to phenotype?
C Jakobs et al.
Journal of inherited metabolic disease, 15(2), 279-280 (1992-01-01)
Nikolaus Sonnenschein et al.
BMC systems biology, 6, 41-41 (2012-05-16)
Integrating gene expression profiles and metabolic pathways under different experimental conditions is essential for understanding the coherence of these two layers of cellular organization. The network character of metabolic systems can be instrumental in developing concepts of agreement between expression
D Darmaun et al.
Journal of chromatography, 620(1), 33-38 (1993-10-22)
A method is described for measuring glutamine (GLN) and alpha-ketoglutarate (KG) concentration and specific activity (SA) using high-performance liquid chromatography (HPLC). Plasma GLN and KG are separated on miniature ion-exchange columns. KG is derivatized with O-phenylene diamine, the derivative is
Andrea Schulze-Bergkamen et al.
Pediatric research, 58(5), 873-880 (2005-09-27)
Organic acid (OAD) and fatty acid oxidation disorders (FAOD) are inborn errors of metabolism often presenting with life-threatening metabolic decompensation followed by (irreversible) organ failure, and even death during catabolic state. Most of these diseases are considered as treatable, and
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