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Merck
CN

72987

Sigma-Aldrich

2-脱氧-2-[(7-硝基-2,1,3-苯并恶二唑-4-基)氨基]-D-葡萄糖

≥97% (HPLC)

别名:

2-NBDG, 2-[N-(7-硝基苯-2-氧杂-1,3-二唑-4-基)氨基]-2-脱氧D-葡萄糖

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About This Item

经验公式(希尔记法):
C12H14N4O8
分子量:
342.26
Beilstein:
7603370
MDL编号:
UNSPSC代码:
12352108
PubChem化学物质编号:
NACRES:
NA.32

生物来源

synthetic

质量水平

方案

≥97% (HPLC)

表单

powder

荧光

λex 494 nm; λem 551 nm in DMSO

应用

cell analysis

储存温度

−20°C

SMILES字符串

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](Nc1ccc([N+]([O-])=O)c2nonc12)C=O

InChI

1S/C12H14N4O8/c17-3-6(11(20)12(21)8(19)4-18)13-5-1-2-7(16(22)23)10-9(5)14-24-15-10/h1-3,6,8,11-13,18-21H,4H2/t6-,8+,11+,12+/m0/s1

InChI key

QUTFFEUUGHUPQC-ILWYWAAHSA-N

一般描述

2-脱氧-2-[(7-硝基-2,1,3-苯并恶二唑-4-基)氨基]-D-葡萄糖,也称2-NBDG,是发射荧光的D葡萄糖类似物。产生的荧光活性通过流式细胞仪检测。2-NBDG与测试样品一起温育并被摄取,然后进行测定。

应用

2-脱氧-2-[(7-硝基-2,1,3-苯并恶二唑-4-基)氨基]-D-葡萄糖可用作直接葡萄糖摄取测定的荧光指示剂。2-NBDG 可用作研究肿瘤细胞的荧光脱氧葡萄糖类似物。 在癫痫活动实验的体内成像中,2-NBDG可用作荧光脱氧葡萄糖类似物。

包装

无底玻璃瓶。内含物装在插入的融合锥内。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Accurately locating epileptic foci has great importance in advancing the treatment of epilepsy. In this study, epileptic seizures were first induced by intracortical injection of 4-aminopyridine in rats. A fluorescent deoxyglucose substitute, 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG), was then continuously injected via the

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