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Merck
CN
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文件

69587

Sigma-Aldrich

2'-（4-甲基伞形酮）-α;-（4-甲基伞形酮）-α- D - N -乙酰神经氨酸 钠盐 水合物

suitable for fluorescence, BioReagent, ≥96.5% (HPLC)

别名:

4-MUNANA, 4-甲基伞形酮辛酸酯-N-乙酰基-α-D-神经氨酸钠盐水合物, 4-甲基伞形酮基- N -乙酰基-α- D -神经氨酸 钠盐 水合物

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About This Item

经验公式（希尔记法）:
C21H24NNaO11 · xH2O
CAS号:
76204-02-9
分子量:
489.41 (anhydrous basis)
UNSPSC代码:
12352106
NACRES:
NA.32

产品线

BioReagent

检测方案

≥96.5% (HPLC)

形式

powder

杂质

≤0.5% free 4-methylumbelliferone
≤10% water

溶解性

H2O: 50 mg/mL, clear, very slightly yellow

荧光

λex 315 nm; λem 374 nm (pH.7.0)
λex 365 nm; λem 445 nm (after cleavage by neuraminidase)

适用性

suitable for fluorescence

储存温度

−20°C

SMILES字符串

O.[H]C(O)(CO)[C@]([H])(O)[C@@H]1OC(C[C@H](O)[C@H]1NC(C)=O)(Oc2ccc3C(C)=CC(=O)Oc3c2)C(=O)O[Na]

InChI

1S/C21H25NO11.Na.H2O/c1-9-5-16(27)31-15-6-11(3-4-12(9)15)32-21(20(29)30)7-13(25)17(22-10(2)24)19(33-21)18(28)14(26)8-23;;/h3-6,13-14,17-19,23,25-26,28H,7-8H2,1-2H3,(H,22,24)(H,29,30);;1H2/q;+1;/p-1/t13-,14?,17+,18?,19+,21+;;/m0../s1

InChI key

NSQMRVBWXQQIKF-NVRWCLOTSA-M

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相关类别

一般描述

2′-(4-甲基伞形酮辛酸酯)-α-D-N-乙酰神经氨酸或 4-MUNANA 是一种合成荧光底物，模仿天然存在的神经氨酸酶底物。 酶-底物水解产生4-甲基伞形酮（4-MU），通过荧光法测定。

应用

2′-(4-甲基伞形酮辛酸酯)-α-D-N-乙酰神经氨酸或 4-MUNANA 用作底物，以开发基于微孔板的神经氨酸酶抑制剂检测。 荧光底物2ʹ-(4-甲基伞形酮辛酸酯)-α-D-N-乙酰神经氨酸（4-MUNANA）用于研究阿司匹林和塞来昔布靶向哺乳动物神经氨酸酶-1 的分子机制。

生化/生理作用

神经氨酸酶荧光测定法的底物。用于 PAGE 中唾液酸酶的荧光染色。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Wei Yang et al.
Carbohydrate research, 359, 92-96 (2012-08-29)
Two novel N-acetylneuraminic acid derivatives, luciferyl N-acetylneuraminic acid (1) and luciferyl 4,7-di-O-methyl-N-acetylneuraminic acid (2), were designed and synthesized as substrates for the rapid detection of influenza virus neuraminidase. The sensitivity and specificity of the assays with compound 1 or 2
Jarinrat Kongkamnerd et al.
Journal of biomolecular screening, 16(7), 755-764 (2011-06-04)
Many assays aimed to test the inhibitory effects of synthetic molecules, and naturally occurring products on the neuraminidase activity exploit the hydrolysis of 2'-O-(4-methylumbelliferyl)-N-acetylneuraminic acid (4-MUNANA). The amount of the released product, 4-methylumbelliferone (4-MU), is then measured fluorimetrically. The authors
A F Li et al.
Drug discoveries & therapeutics, 3(6), 260-265 (2009-12-01)
Neuraminidase (NA) represents a highly promising new target for drug development in influenza virus genes. Rapid screening of enzyme inhibitors is a key method for the identification of leading compounds. In order to speed up the screening for enzyme inhibitors
Macarena P Quintana-Hayashi et al.
Infection and immunity, 87(7) (2019-04-17)
Infection with Brachyspira hyodysenteriae results in mucoid hemorrhagic diarrhea. This pathogen is associated with the colonic mucus layer, mainly composed of mucins. Infection regulates mucin O-glycosylation in the colon and increases mucin secretion as well as B. hyodysenteriae binding sites
Patrice Guillon et al.
Nature communications, 5, 5268-5268 (2014-10-21)
Human parainfluenza viruses (hPIVs) cause upper and lower respiratory tract disease in children that results in a significant number of hospitalizations and impacts health systems worldwide. To date, neither antiviral drugs nor vaccines are approved for clinical use against parainfluenza
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