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68957

Sigma-Aldrich

三 2-羰基乙基 磷盐酸盐 盐酸盐

BioUltra, suitable for electrophoresis, SDS-PAGE tested

别名:

TCEP.HCL, TCEP

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About This Item

经验公式（希尔记法）:
C9H15O6P · HCl
CAS号:
51805-45-9
分子量:
286.65
Beilstein:
3724376
MDL编号:
MFCD00145469
UNSPSC代码:
12352128
PubChem化学物质编号:
329761275
NACRES:
NA.32

产品线

BioUltra

质量水平

100

方案

97.5-102.5%

表单

powder

技术

electrophoresis: suitable

溶解性

H2O: soluble

适用性

SDS-PAGE tested

SMILES字符串

Cl[H].OC(=O)CCP(CCC(O)=O)CCC(O)=O

InChI

1S/C9H15O6P.ClH/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15;/h1-6H2,(H,10,11)(H,12,13)(H,14,15);1H

InChI key

PBVAJRFEEOIAGW-UHFFFAOYSA-N

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相关类别

一般描述

三（2-羧乙基）膦盐酸（TCEP.HCl）是一种可用于含硫和含氮化合物的有用还原剂。TCEP.HCL及其产生的氧化物是水溶性的。 TCEP.HCL 具有富含电子的磷和氧原子，可以多种金属结合，如铑、铱、帕。在室温下它可在二恶烷中与铑和铱快速络合。 它可以还原各种肽和蛋白质中的二硫键。

应用

TCEP.HCL 已被用于体内和体外的多种生物偶联应用，用于标记蛋白质和活生物，在温和的生理环境下具有良好的有效性。 TCEP.HCL适用于各种生物和合成应用。在酸性pH下，TCEP.HCL 可用于在水中不可逆地将有机二硫化物转化为硫醇。
水溶性试剂，用于二硫化物的选择性还原。在质谱应用中比 DTT 更稳定。

特点和优势

该产品具有以下优点：

  • TCEP.HCL 降低活性氧水平。
  • 它提高谷胱甘肽和线粒体含量。
  • 它具有抗癌作用。

分析说明

琼脂糖凝胶电泳符合要求

象形图

Corrosion
GHS05

警示用语：

Danger

危险声明

H314

危险分类

Eye Dam. 1 - Skin Corr. 1B

储存分类代码

8A - Combustible corrosive hazardous materials

WGK

WGK 1

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM5857
BCCH3116
BCCG6486
BCCG0947
BCCD4753

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Christopher R Schlieve et al.
Experimental eye research, 83(5), 1252-1259 (2006-08-29)
Retinal ganglion cells (RGCs) undergo apoptosis after axonal injury, in part regulated by an intracellular superoxide anion burst, for which the target(s) are unknown. Shifting the RGC redox state towards reduction and preventing sulfhydryl oxidation is neuroprotective in vitro and
W H Fischer et al.
Rapid communications in mass spectrometry : RCM, 7(3), 225-228 (1993-03-01)
The suitability of the hydrochloride salt of tris(2-carboxyethyl)phosphine (TCEP) for in situ reduction with matrix-assisted laser desorption/ionization (MALDI) and liquid secondary ionization (LSI) mass spectrometry is evaluated. TCEP can be used to irreversibly reduce organic disulfides to thiols in water
Yiren Zeng et al.
Theriogenology, 162, 32-41 (2021-01-15)
Oocyte in vitro maturation (IVM) is a crucial process that determines subsequent in vitro embryo production. The present study investigated the effects of the antioxidant tris (2-carboxyethyl) phosphine hydrochloride (TCEP-HCL) on the in vitro maturation of porcine oocytes and in vitro developmental competence of
Siming Chen et al.
Chemical communications (Cambridge, England), 49(12), 1226-1228 (2013-01-05)
A widely used reducing agent tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein. This discovery clarifies the reactivity of cisplatin towards Sp1 zinc finger protein and implies that the reactions of platinum drugs could be
Fang-Fang Cheng et al.
The Analyst, 139(16), 3860-3865 (2014-07-01)
The expression of microRNAs (miRNAs) is related to some cancer diseases. Recently, miRNAs have emerged as new candidate diagnostic and prognostic biomarkers for detecting a wide variety of cancers. Due to low levels, short sequences and high sequence homology among
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