68783
甘草查尔酮A
≥96.0% (HPLC)
别名:
(E)-3- [5-（1,1-二甲基-2-丙烯基）-4-羟基-2-甲氧基苯基]-1-（4-羟基苯基）-2-丙烯-1-酮, 4′1,4-二羟基-3-α,α-二甲基烯丙基-6-甲氧基查尔酮
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关于此项目
经验公式（希尔记法）:
C21H22O4
化学文摘社编号:
分子量:
338.40
UNSPSC Code:
41116107
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4534154
产品名称
甘草查尔酮A, ≥96.0% (HPLC)
InChI
1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+
SMILES string
COc1cc(O)c(cc1\C=C\C(=O)c2ccc(O)cc2)C(C)(C)C=C
InChI key
KAZSKMJFUPEHHW-DHZHZOJOSA-N
assay
≥96.0% (HPLC)
form
powder
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
抑制芽孢形成细菌 枯草芽孢杆菌 和其他食品污染微生物的营养生长。
General description
Licochalcone A 是一种强效膜活性剂，可将正常红细胞转化为棘形红细胞。一种具有显著抗肿瘤活性的新型黄酮类化合物。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Chian-Jiun Liou et al.
Cells, 8(5) (2019-05-15)
Licochalcone A is a chalcone isolated from Glycyrrhiza uralensis. It showed anti-tumor and anti-inflammatory properties in mice with acute lung injuries and regulated lipid metabolism through the activation of AMP-activated protein kinase (AMPK) in hepatocytes. However, the effects of licochalcone
Megumi Funakoshi-Tago et al.
Molecular pharmacology, 76(4), 745-753 (2009-07-14)
Glycyrrhiza inflata has been used as a traditional medicine with anti-inflammatory activity; however, its mechanism has not been fully understood. Licochalcone A is a major and biogenetically characteristic chalcone isolated from G. inflata. Here, we found that licochalcone A strongly
Xiao Chu et al.
Journal of agricultural and food chemistry, 60(15), 3947-3954 (2012-03-10)
Licochalcone A (Lico A), a flavonoid found in licorice root (Glycyrrhiza glabra), is known for its antimicrobial activity and its reported ability to inhibit cancer cell proliferation. In the present study, we found that Lico A exerted potent anti-inflammatory effects
Yi-Te Yo et al.
Journal of agricultural and food chemistry, 57(18), 8266-8273 (2009-08-29)
Licorice is a common Chinese medicinal herb with antitumor activity. Some components in licorice root have been shown to induce cell cycle arrest or apoptosis in cancer cells. This paper demonstrates for the first time that licorice Glycyrrhiza glabra and
Yoon Hee Kim et al.
Biochemical pharmacology, 80(8), 1152-1159 (2010-07-20)
To date, no antiangiogenic activity has been demonstrated for licochalcone A (LicA), a major phenolic constituent of Glycyrrhiza inflata, although it shows significant antitumor activity in human malignant cell lines. Our previous work demonstrated that LicA down-regulates inflammatory responses to
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