生物来源
synthetic
质量水平
偶联物
FITC conjugate
形式
powder or crystals
分子量
average mol wt 4,000
组成
carboxymethyl content, 3-7%
标记范围
0.001-0.020 mol/mol FITC glucose
技术
permeability assay: suitable
荧光
λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0
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一般描述
FITC-CM-葡聚糖，也称异硫氰酸荧光素–羧甲基–葡聚糖，是一种阴离子荧光探针。羧基提供了负电荷，其改善分子的总体渗透性。它是以黄色粉末形式供货，易溶于水和电解质溶液。FITC-CM-葡聚糖不溶于大多数有机样品，如乙醇、甲醇、丙酮和氯仿。FITC-CM-葡聚糖是通过选定的葡聚糖与活化的羧甲基衍生物在碱中反应制造，通过反应O-甲氧基被引入葡聚糖链。
应用
FITC-CM-葡聚糖用于研究HeLa 细胞系中的药物摄入和输送机制。选择FITC-CM-葡聚糖是因为其水溶性高并带负电。 它也是胶囊化研究的合适分子，可用于聚合物囊泡药物递送体系（或称Ps DDS）。选择FITC-CM-葡聚糖是一种生物相容性分子，可用作多种制药和诊断应用中的起始原料。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Yuxin Leng et al.
PloS one, 9(10), e109350-e109350 (2014-10-09)
Intra-abdominal hypertension (IAH) is known as a common, serious complication in critically ill patients. Bacterial translocation and permeability changes are considered the pathophysiological bases for IAH-induced enterogenic endotoxemia and subsequent multiorgan failure. Nevertheless, the effects of slightly elevated intra-abdominal pressures
Stefanie J Anderson et al.
Comparative medicine, 69(1), 4-15 (2018-12-14)
Here we characterized the murine dextran sulfate sodium (DSS) model of acute colitis. Specifically, we evaluated azithromycin and metronidazole treatment regimens to assess their effects on animal wellbeing, pathologic changes, barrier function, cytokine and chemokine profiles, and neutrophil migration in
Yuxin Leng et al.
Scientific reports, 6, 22814-22814 (2016-03-17)
Intra-abdominal hypertension (IAH) is a common and serious complication in critically ill patients for which there is no well-defined treatment strategy. Here, we explored the effect of IAH on multiple intestinal barriers and discussed whether the alteration in microflora provides
Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats.
Harada M, Murata J, Sakamura Y, et al.
J. Controlled Release, 71, 71-86 (2001)
Chloe Martin et al.
International journal of pharmaceutics, 511(1), 570-578 (2016-07-28)
The need to develop a greater understanding of drug delivery systems has arisen through the development of alternative biological based therapeutics. Drug delivery systems need to adapt and respond to this increasing demand for cellular transportation of highly charged species.
商品
包括FITC-葡聚糖、FITC-DEAE-葡聚糖(FDD)、FITC-羧甲基 - 葡聚糖（FCM-葡聚糖）在内的FITC标记多糖的补充信息。本页面主要介绍了重均分子量对于对应分子尺寸和其他物理性质的影响
Explore FITC-labelled polysaccharides and their properties, including impact of molecular weight on molecule dimensions.
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