64951
7-甲氧基香豆素
suitable for fluorescence, ≥98.0% (TLC)
别名:
Methyl umbelliferyl ether, 赫尼亚林
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关于此项目
经验公式（希尔记法）:
C10H8O3
化学文摘社编号:
分子量:
176.17
UNSPSC Code:
85151701
NACRES:
NA.32
PubChem Substance ID:
EC Number:
208-513-3
Beilstein/REAXYS Number:
141728
MDL number:
InChI key
LIIALPBMIOVAHH-UHFFFAOYSA-N
InChI
1S/C10H8O3/c1-12-8-4-2-7-3-5-10(11)13-9(7)6-8/h2-6H,1H3
SMILES string
COc1ccc2C=CC(=O)Oc2c1
assay
≥98.0% (TLC)
form
solid
mp
117-121 °C (lit.)
solubility
DMF: soluble, acetonitrile: soluble, alcohols: soluble, chloroform: soluble
fluorescence
λex 350 nm; λem 385 nm (Reaction product), λex 350 nm; λem 385 nm in chloroform
suitability
suitable for fluorescence
Quality Level
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Application
7-Methoxycoumarin (Herniarin) is used to study antioxidant and hepatoprotective properties and its activity as an allergen. 7-Methoxycoumarin may be used as a reference material in the purification, separation and analysis of coumarin compounds.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Sandesh Sancheti et al.
Drug and chemical toxicology, 36(1), 42-47 (2012-11-07)
The available conventional remedies for the treatment of drug-induced liver diseases are highly inadequate and possess serious adverse effects; therefore, the development of new, effective drugs is considered necessary. This article explores the hepatoprotective and antioxidant potential of 7-methylcoumarin (MC)
[Absorption and excretion of apigenin, apigenin-7-glycoside and herniarin after oral administration of extracts of Matricaria recutita (L.) (syn. Chamomilla recutita (L.) Rauschert)].
K Tschiersch et al.
Die Pharmazie, 48(7), 554-555 (1993-07-01)
M Warren et al.
Xenobiotica; the fate of foreign compounds in biological systems, 18(8), 973-981 (1988-08-01)
1. The activities of 7-methoxycoumarin (7-MCOD), 7-ethoxycoumarin (7-ECOD) and 7-propoxycoumarin (7-PCOD) O-dealkylases decreased by 75-90% during culture of rat hepatocytes for 72 h. 2. The addition of dexamethasone (D) produced a stabilization or modest enhancement of 7-ECOD and 7-PCOD activities
Chao-Mei Ma et al.
Phytochemical analysis : PCA, 18(1), 42-49 (2007-01-31)
A simple HPLC-PAD-MS method was established to quantitatively analyse two spiroether isomers (cis-en-yn-dicycloether and trans-en-yn-dicycloether) and the main coumarin, herniarin, in chamomile herbs, simultaneously. By using this method, the contents of these three compounds in the flowers of two chamomile
P Paterson et al.
Xenobiotica; the fate of foreign compounds in biological systems, 14(11), 849-859 (1984-11-01)
Pretreatment of rats with phenobarbitone increased hepatic microsomal 7-methoxy-and 7-ethoxy-coumarin O-dealkylase activities. Pretreatment with beta-naphthoflavone increased only the 7-ethoxycoumarin O-dealkylase activity. The addition of metyrapone in vitro inhibited the O-dealkylations to different extents. Similar results were obtained with diphenyloxazole and
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