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Merck
CN

64382

Sigma-Aldrich

DL -甲硫氨酸甲磺酰氯

≥97.0% (AT)

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别名:
MMS, 甲基蛋氨酸氯化磺铵, 维生素U, (3-氨基-3-羧丙基)二甲基磺酰氯
经验公式(希尔记法):
C6H14ClNO2S
CAS号:
分子量:
199.70
Beilstein:
4163617
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26

生物来源

synthetic

检测方案

≥97.0% (AT)

形式

powder

杂质

≤0.002% heavy metals

灼烧残渣

≤0.1%

缺失

≤3% loss on drying

颜色

colorless to white

pH值(酸碱度)

4.0-5.5

mp

139-140 °C

溶解性

H2O: 100 mg/mL, clear, colorless

SMILES字符串

[Cl-].C[S+](C)CCC(N)C(O)=O

InChI

1S/C6H13NO2S.ClH/c1-10(2)4-3-5(7)6(8)9;/h5H,3-4,7H2,1-2H3;1H

InChI key

MYGVPKMVGSXPCQ-UHFFFAOYSA-N

生化/生理作用

DL-蛋氨酸甲磺 (DL-MMSC) 是一种外消旋混合物,用于研究其保护胃溃疡的机制。DL-MMSC 也可用作蛋氨酸类似物。
S-蛋氨酸甲基 (SMMS) 氯化物是某些植物蛋氨酸代谢的衍生物。SMMS可以过促进皮肤成纤维细胞迁移和生长能力,对胃肠道溃疡具有有效的治疗作用。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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Takafumi Ichikawa et al.
Journal of gastroenterology and hepatology, 24(3), 488-492 (2009-01-30)
In Japan, peptic ulcer disease (PUD) is treated clinically with a combination of a mucosal protectant and acid suppressants, but there is scant information regarding the effects of these drugs on normal gastric mucus cells. In the present study, the
Effect of s-methylmethionine sulphonium chloride on oesophagogastric ulcers in pigs.
Kopinski JS, Fogarty R, McVeigh J.
Australian Journal of Chemistry, 85, 362-367 (2007)
A S Salim
Pharmacology, 46(5), 281-288 (1993-05-01)
This prospective randomized double-blind controlled study investigated whether sulphydryl-containing agents protect against the recurrence of duodenal ulceration. To this end, DL-cysteine (200 mg 4 times daily) and DL-methionine-methyl sulphonium chloride (MMSC, 500 mg 4 times daily) were administered orally. Three
A S Salim
Journal of pharmaceutical sciences, 81(7), 698-700 (1992-07-01)
Reserpine (intraperitoneal, 5 mg/kg every day for 5 days) produced chronic ulceration of the rat stomach 2 weeks postdose. Gavage with 1% DL-cysteine or DL-methionine-S-methylsulfonium chloride at 1 mL/day for 2 weeks and 5 days protected against ulceration in 30%
Kinuyo Matsumoto et al.
Metallomics : integrated biometal science, 3(7), 683-685 (2011-06-28)
The insulinomimetic activity of a Zn(ii) complex is reported. The effects of the Zn(ii) complex with ascorbic acid (Vitamin C; VC), methylmethionine sulfonium chloride (Vitamin U; VU) and l-carnitine were assessed in diet-induced metabolic syndrome model rats. Zn(VU)(2)Cl(2) and Zn(VC)Cl(2)

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