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The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
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主要文件

61962

Sigma-Aldrich

甜菜碱

BioUltra, ≥99.0% (NT)

别名:

Oxyneurine, Trimethylglycine, (羧甲基)三甲胺 内盐

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About This Item

线性分子式:
(CH3)3N+CH2COO-
CAS号:
分子量:
117.15
Beilstein:
3537113
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.25

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产品线

BioUltra

方案

≥99.0% (NT)

杂质

insoluble matters, passes filter test

溶解性

methanol: 1 M at 20 °C, clear, colorless

痕量阴离子

chloride (Cl-): ≤200 mg/kg
sulfate (SO42-): ≤200 mg/kg

痕量阳离子

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤100 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

吸附

≤0.05 at 280 nm in methanol at 1 M
≤0.09 at 260 nm in methanol at 1 M

SMILES字符串

C[N+](C)(C)CC([O-])=O

InChI

1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3

InChI key

KWIUHFFTVRNATP-UHFFFAOYSA-N

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我们全面的上游工艺化学品系列不仅为生物制药生产商提供生产传统和创新治疗药物所需的优质原料,而且帮助他们更快地将产品投放市场并简化监管问题。 请相信我们能够为您带来透明的供应链和可靠的全球采购能力,以最佳的法规支持和服务简化您的产品认证。

应用

甜菜碱已被用于逆转录以增加蛋白质的热稳定性并使DNA螺旋脱稳。[1]

生化/生理作用

甜菜碱已被证明可增加S-腺苷甲硫氨酸(SAM)水平,因此可能在减少肝脏脂肪变性方面发挥作用。它是一种渗透压保护剂,可保护细胞免受环境压力的影响。[2][3]
甜菜碱是胆碱氧化代谢的终产物,是一种通用的甲基供体,特别存在于甲硫氨酸生物合成的一个次要途径中。它被用于治疗同型半胱氨酸尿症,一种在蛋氨酸生物合成主要途径的缺陷。[4]

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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    分析证书(COA)

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    Full-length RNA-seq from single cells using Smart-seq2.
    Picelli S
    Nature Protocols, 9(1), 171-181 (2014)
    Varsha Mathur et al.
    Current biology : CB, 29(17), 2936-2941 (2019-08-20)
    The apicomplexans are a group of obligate animal pathogens that include Plasmodium (malaria), Toxoplasma (toxoplasmosis), and Cryptosporidium (cryptosporidiosis) [1]. They are an extremely diverse and specious group but are nevertheless united by a distinctive suite of cytoskeletal and secretory structures related to
    Shangli Cheng et al.
    Cell reports, 26(10), 2593-2607 (2019-03-07)
    Following implantation, the epiblast (EPI) cells transit from the naive to primed pluripotency, accompanied by dynamic changes in X chromosome activity in females. To investigate the molecular attributes of this process, we performed single-cell RNA-seq analysis of 1,724 cells of
    M R Olthof et al.
    Current drug metabolism, 6(1), 15-22 (2005-02-22)
    High plasma concentrations of homocysteine may increase risk of cardiovascular disease. Folic acid lowers plasma homocysteine by 25% maximally, because 5-methyltetrahydrofolate is a methyl donor in the remethylation of homocysteine to methionine. Betaine (trimethylglycine) is also a methyl donor in
    Stuart A S Craig
    The American journal of clinical nutrition, 80(3), 539-549 (2004-08-24)
    Betaine is distributed widely in animals, plants, and microorganisms, and rich dietary sources include seafood, especially marine invertebrates ( approximately 1%); wheat germ or bran ( approximately 1%); and spinach ( approximately 0.7%). The principal physiologic role of betaine is

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