生物来源
human milk
质量水平
检测方案
≥85% (GE)
形式
solid
质量
iron-saturated
分子量
82.4 kDa
浓度
≥0.15 % (w/w) Fe
溶解性
0.05 M NaCl: 1 mg/mL, clear to faintly turbid, faintly red to brown
UniProt登记号
储存温度
2-8°C
InChI
1S/C35H53N9O12/c1-16(2)27(43-33(53)23(14-26(47)48)41-25(46)15-38-29(49)18(5)39-31(51)21(36)13-24(37)45)34(54)40-19(6)30(50)42-22(12-20-10-8-7-9-11-20)32(52)44-28(17(3)4)35(55)56/h7-11,16-19,21-23,27-28H,12-15,36H2,1-6H3,(H2,37,45)(H,38,49)(H,39,51)(H,40,54)(H,41,46)(H,42,50)(H,43,53)(H,44,52)(H,47,48)(H,55,56)/t18-,19-,21-,22-,23-,27-,28-/m0/s1
InChI key
QCBUWCQOKPLTDZ-PKRULZLPSA-N
基因信息
human ... LTF(4057)
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应用
Lactoferrin was used for development of lactoferrin immunosensor.
生化/生理作用
乳铁蛋白是一种铁结合蛋白。在结构上与血浆铁转运蛋白转铁蛋白相似；但是乳铁蛋白对铁的亲和力要高得多（250 倍）。在初乳中含量非常丰富，少量也可见于泪液、唾液、粘液分泌物和中性粒细胞的次级颗粒中。由粘膜上皮和中性粒细胞组成，在炎症刺激下由这些细胞释放。细菌的生长被其隔离铁的能力所抑制，也通过其 N 端与脂多糖结合使细菌细胞壁通透性增加。乳铁蛋白可以通过与病毒包膜蛋白紧密结合来抑制病毒感染。它通过阻断结合域阻止了细胞与病毒的融合。乳铁蛋白似乎部分通过刺激中性粒细胞激活剂白细胞介素-8 的释放来激活宿主防御系统。还可能参与抗体和白细胞介素合成、淋巴细胞增殖和补体激活。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Luigi Campanella et al.
Journal of pharmaceutical and biomedical analysis, 53(2), 186-193 (2010-04-17)
The last year we fabricated some new immunosensors for the analysis of lactoferrin protein. In the present research the immunological and analytical characteristics of the immunosensor method have been extensively investigated. The study was therefore extended to cover the ability
Gregory T Spear et al.
PloS one, 6(5), e19560-e19560 (2011-05-17)
More than one million new cases of sexually transmitted diseases (STDs) occur each day. The immune responses and inflammation induced by STDs and other frequent non-STD microbial colonizations (i.e. Candida and bacterial vaginosis) can have serious pathologic consequences in women
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