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59464

Sigma-Aldrich

2-甲基枸橼酸三钠，非对映体的外消旋混合物

≥85% (mixture of diastereomers, NMR)

别名:

3-羧基-3-羟基-2-甲基-戊二酸三钠

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About This Item

经验公式（希尔记法）:
C7H7Na3O7
CAS号:
117041-96-0
分子量:
272.10
MDL编号:
MFCD16875437
UNSPSC代码:
12352107
PubChem化学物质编号:
329758670
NACRES:
NA.25

质量水平

100

方案

≥85% (mixture of diastereomers, NMR)

表单

solid

杂质

≤5% water

SMILES字符串

[Na+].[Na+].[Na+].CC(C([O-])=O)C(O)(CC([O-])=O)C([O-])=O

InChI

1S/C7H10O7.3Na/c1-3(5(10)11)7(14,6(12)13)2-4(8)9;;;/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13);;;/q;3*+1/p-3

InChI key

HPLKAWNRQOHUKD-UHFFFAOYSA-K

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应用

2-甲基枸橼酸盐是2-甲基柠檬酸（2-MCA）循环的一种成分，该循环利用丙酸盐作为细菌的碳源和能量源。2-甲基枸橼酸三钠可用于研究该途径

生化/生理作用

MCA是一种诊断标志物代谢物，累积在患有以下遗传性代谢疾病的患者的体液中：丙酸血症（PA）、甲基丙二酸血症（MMA）、全羧化酶合成酶缺乏症（HCSD）。MCA以（2S，3S）-和（2R，3S）-立体异构体的混合物形式出现。

包装

无底玻璃瓶。内含物装在插入的融合锥内。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
BCCF5393
BCBW7168
BCBB6963V
BCBB6963

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Sagar Chittori et al.
Journal of structural biology, 174(1), 58-68 (2010-10-26)
2-Methylcitric acid (2-MCA) cycle is one of the well studied pathways for the utilization of propionate as a source of carbon and energy in bacteria such as Salmonella typhimurium and Escherichia coli. 2-Methylcitrate synthase (2-MCS) catalyzes the conversion of oxaloacetate
S Cheema-Dhadli et al.
Pediatric research, 9(12), 905-908 (1975-12-01)
2-Methylcitrate was tested in vitro on enzymes which interact with citrate and isocitrate. It was found to inhibit citrate synthase, aconitase, the NAD+- and NADP+-linked isocitrate dehydrogenase. This inhibition was competitive in nature except in the case of aconitase, and
Characterization of the 1H and 13C NMR spectra of methylcitric acid.
Krawczyk, H. and Martyniuk, T.
Spectrochimica Acta Part A: Molecular Spectroscopy, 67, 298-305 (2007)
Sagar Chittori et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 66(Pt 4), 467-470 (2010-04-13)
Analysis of the genomic sequences of Escherichia coli and Salmonella typhimurium has revealed the presence of several homologues of the well studied citrate synthase (CS). One of these homologues has been shown to code for 2-methylcitrate synthase (2-MCS) activity. 2-MCS
Sergio Palacios et al.
Journal of bacteriology, 185(9), 2802-2810 (2003-04-18)
The studies reported here identify propionyl coenzyme A (propionyl-CoA) as the common intermediate in the 1,2-propanediol and propionate catabolic pathways of Salmonella enterica serovar Typhimurium LT2. Growth on 1,2-propanediol as a carbon and energy source led to the formation and
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