57672
N-碘乙酰-N′-(5-磺基-1-萘)乙二胺
suitable for fluorescence, ≥95% (HPLC)
别名:
1,5-I-AEDANS, 5-[2-(碘乙酰氨基)乙氨基]萘-1-磺酸, N-碘乙酰基-N′-(5-磺基-1-萘基)乙二胺, Hudson-Weber 试剂
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关于此项目
线性分子式:
ICH2CONHCH2CH2NHC10H6SO3H
化学文摘社编号:
分子量:
434.25
UNSPSC Code:
12352200
PubChem Substance ID:
eCl@ss:
32035301
EC Number:
253-277-7
Beilstein/REAXYS Number:
3004454
MDL number:
InChI key
ZMERMCRYYFRELX-UHFFFAOYSA-N
InChI
1S/C14H15IN2O4S/c15-9-14(18)17-8-7-16-12-5-1-4-11-10(12)3-2-6-13(11)22(19,20)21/h1-6,16H,7-9H2,(H,17,18)(H,19,20,21)
SMILES string
OS(=O)(=O)c1cccc2c(NCCNC(=O)CI)cccc12
assay
≥95% (HPLC)
fluorescence
λex 336 nm; λem 490 nm (pH 8.0), λex 337 nm; λem 498 nm (after derivatization with 2-mercaptoethanol)
suitability
suitable for fluorescence
storage temp.
2-8°C
Application
N-(Iodoacetaminoethyl)-1-naphthylamine-5-sulfonic acid (1,5-I-AEDANS) is a fluorescence probe used to label protein sulfhydryls to study conformational changes, fluorescence anisotropy and protein:protein interactions.
Other Notes
Fluorescent sulfhydryl reagent
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Samrat Mukhopadhyay et al.
Journal of molecular biology, 358(4), 935-942 (2006-03-21)
The small protein barstar aggregates at low pH to form soluble oligomers, which can be transformed into fibrillar aggregates at an elevated temperature. To characterize structurally, with residue-specific resolution, the process of amyloid formation of barstar, as well as to
Torsten Heidenreich et al.
The Journal of biological chemistry, 280(6), 4213-4218 (2004-11-25)
The molybdenum cofactor sulfurase ABA3 from Arabidopsis thaliana specifically regulates the activity of the molybdenum enzymes aldehyde oxidase and xanthine dehydrogenase by converting their molybdenum cofactor from the desulfo-form into the sulfo-form. ABA3 is a two-domain protein with an NH2-terminal
Jason R Waggoner et al.
Biochemistry, 46(7), 1999-2009 (2007-01-31)
We have used steady-state fluorescence spectroscopy in combination with enzyme kinetic assays to test the hypothesis that phospholamban (PLB) stabilizes the Ca-ATPase in the E2 intermediate state. The cardiac muscle Ca-ATPase (SERCA2a) isoform was expressed either alone or coexpressed with
Adrienne Clements et al.
Analytical chemistry, 77(14), 4495-4502 (2005-07-15)
This study demonstrates that 1,5-I-AEDANS (5-({2-[(iodoacetyl)amino]ethyl}amino)naphthalene-1-sulfonic acid) can be used as a versatile fluorescence-based peptide quantification tool and provides readily interpretable tandem mass spectra for de novo peptide sequencing. Two AEDANS-cysteinyl-peptide fractionation strategies were evaluated. One AEDANS-cysteinyl-peptide fractionation strategy employs
Zofia Ostrowska-Podhorodecka et al.
Archives of biochemistry and biophysics, 682, 108280-108280 (2020-01-31)
Tropomyosin and cofilin are involved in the regulation of actin filament dynamic polymerization and depolymerization. Binding of cofilin changes actin filaments structure, leading to their severing and depolymerization. Non-muscle tropomyosin isoforms were shown before to differentially regulate the activity of
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