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Merck
CN
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文件

安全信息

57180

Sigma-Aldrich

Indo 1

for fluorescence, ≥80.0% (HPLC)

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别名:
4-(6-Carboxy-2-indolyl)-4′-methyl-2,2′-(ethylenedioxy)dianiline-N,N,N′,N′-tetraacetic acid pentapotassium salt
经验公式（希尔记法）:
C32H26K5N3O12
CAS号:
132319-56-3
分子量:
840.05
MDL编号:
MFCD00077797
UNSPSC代码:
12352200
PubChem化学物质编号:
329758276
NACRES:
NA.32

等级

for fluorescence

检测方案

≥80.0% (HPLC)

形式

solid

荧光

λex 331 nm; λem 398 nm in 0.1 M Tris pH 8.0, 10 mM Ca2+
λex 349 nm; λem 482 nm (100mM KCI)

适用性

in accordance for fluorescence

储存温度

−20°C

SMILES字符串

[K+].[K+].[K+].[K+].[K+].Cc1ccc(N(CC([O-])=O)CC([O-])=O)c(OCCOc2cc(ccc2N(CC([O-])=O)CC([O-])=O)-c3cc4ccc(cc4[nH]3)C([O-])=O)c1

InChI

1S/C32H31N3O12.5K/c1-18-2-6-24(34(14-28(36)37)15-29(38)39)26(10-18)46-8-9-47-27-13-20(5-7-25(27)35(16-30(40)41)17-31(42)43)22-11-19-3-4-21(32(44)45)12-23(19)33-22;;;;;/h2-7,10-13,33H,8-9,14-17H2,1H3,(H,36,37)(H,38,39)(H,40,41)(H,42,43)(H,44,45);;;;;/q;5*+1/p-5

InChI key

VGZPRMSXVNDMAN-UHFFFAOYSA-I

应用

Indo 1, a fluorescent calcium chelator and indicator, is used to monitor cytoplasmic Ca2+ transients induced by various physiological and mechanical processes.

其他说明

Fluorescent calcium chelator and indicator with an unusually large shift in fluorescence emission from 480 nm to 400 nm on binding of calcium. Useful for intracellular application

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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Wanwarang Wongcharoen et al.
Cardiovascular research, 70(3), 497-508 (2006-04-01)
Pulmonary veins (PVs) are the most important focus for generation of atrial fibrillation. The Na(+)/Ca(2+) exchange (NCX) current is important in PV electrical activity and cardiac glycosides-induced arrhythmias. The purpose of this study was to investigate whether KB-R7943, a NCX
Terence R Moopanar et al.
The Journal of physiology, 571(Pt 1), 191-200 (2005-12-13)
The aim of this study was to further characterize the reduction of myofibrillar Ca2+ sensitivity in mouse muscle which has been observed after fatigue at 37 degrees C. Muscle bundles and single fibres were isolated from mouse flexor digitorum brevis
Yael Yaniv et al.
PloS one, 7(5), e37582-e37582 (2012-06-06)
Mitochondria dynamically buffer cytosolic Ca(2+) in cardiac ventricular cells and this affects the Ca(2+) load of the sarcoplasmic reticulum (SR). In sinoatrial-node cells (SANC) the SR generates periodic local, subsarcolemmal Ca(2+) releases (LCRs) that depend upon the SR load and
K Nishimaru et al.
British journal of pharmacology, 152(4), 456-463 (2007-07-21)
The potent vasoconstrictor polypeptide endothelin-1 (ET-1) plays an important pathophysiological role in progression of cardiovascular diseases and elicits prominent effects on myocardial contractility. Although ET-1 produces a positive inotropy in cardiac muscle of most mammalian species, it induces a sustained
Microsphere-based real-time calcium sensing.
Rosario M Sánchez-Martín et al.
Angewandte Chemie (International ed. in English), 45(33), 5472-5474 (2006-07-19)
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