55345
N-Methyl-L-threonine
≥98% (TLC)
别名:
(2S,3R)-3-Hydroxy-2-(methylamino)butyric acid, N-Me-Thr-OH
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关于此项目
经验公式（希尔记法）:
C5H11NO3
化学文摘社编号:
分子量:
133.15
PubChem Substance ID:
UNSPSC Code:
12352202
Beilstein/REAXYS Number:
1722279
MDL number:
SMILES string
CN[C@@H]([C@@H](C)O)C(O)=O
InChI
1S/C5H11NO3/c1-3(7)4(6-2)5(8)9/h3-4,6-7H,1-2H3,(H,8,9)/t3-,4+/m1/s1
InChI key
CCAIIPMIAFGKSI-DMTCNVIQSA-N
assay
≥98% (TLC)
form
powder
optical activity
[α]/D -24.0±1.0°, c = 1 in 1 M HCl
composition
carbon, 44.2-46.0% , nitrogen, 10.3-10.8%
color
white
storage temp.
2-8°C
Biochem/physiol Actions
N-Methyl amino acids play an important role in investigations on prevention or therapy of Alzheimer′s disease, neurofibrillary tangles or amyloid plaque are physiological characteristics of this disease and ?-amyloid(40) fibrillogenesis and disassembly of ?-amyloid(40) fibrils is inhibited by short ?-amyloid congeners containing N-methyl amino acids at alternate residue.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
D J Gordon et al.
Biochemistry, 40(28), 8237-8245 (2001-07-11)
A potential goal in the prevention or therapy of Alzheimer's disease is to decrease or eliminate neuritic plaques composed of fibrillar beta-amyloid (Abeta). In this paper we describe N-methyl amino acid containing congeners of the hydrophobic "core domain" of Abeta
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