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Merck
CN
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文件

53747

Sigma-Aldrich

透明质酸 钠盐 来源于马链球菌

bacterial glycosaminoglycan polysaccharide

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别名:
聚（β-葡萄糖醛酸-[1→3]-β-N-乙酰葡糖胺-[1→4]），交替
CAS号:
9067-32-7
UNSPSC代码:
51202002
PubChem化学物质编号:
24878223
NACRES:
NA.25

生物来源

(Streptococcus equi)

质量水平

200

形式

powder or crystals

分子量

~1.5-1.8 x 10E6 Da

杂质

≤1% protein

颜色

white

溶解性

H2O: 5 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

[Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2C([O-])=O

InChI

1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1

InChI key

YWIVKILSMZOHHF-QJZPQSOGSA-N

相关类别

一般描述

透明质酸（HA）是中枢神经系统细胞外基质的重要组分，是在所有脊椎动物结缔组织中都能发现的多功能大分子。这种超分子糖胺聚糖是一种聚阴离子天然聚合物，以线性多糖的形式存在。它由葡萄糖醛酸和N-乙酰氨基葡萄糖通过β-1,4键重复组成。透明质酸在眼睛、关节和心脏瓣膜中大量存在。

应用

马链球菌透明质酸钠盐已用于：
  • 与甲基丙烯酸酐合成交联甲基丙烯酸 HA 水凝胶（Coll-MeHA）
  • 在磷酸盐缓冲盐水（PBS）中取代 PBS 浴槽来改变润滑剂成分
  • 制备润滑剂，以研究对人体骨关节炎（OA）软骨边界润滑的影响

生化/生理作用

透明质酸（HA）是滑膜液和关节软骨的重要组分，起边界润滑剂的作用。它具有多种物理化学性质，包括生物可降解性、生物相容性、无毒性和非免疫原性。透明质酸被认为是生物医学用途的重要工具，如药物输送、组织工程、整形外科、眼科手术和骨关节炎手术。它参与身体缓冲和润滑。这种强大的抗氧化剂可以将水与组织结合。

其他说明

为了全面了解我们针对客户研究提供的各种多糖产品，建议您访问我们的碳水化合物分类页面。

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the molecular weight of Product 53747, Hyaluronic acid sodium salt from Streptococcus equi?

    According to our supplier, the molecular weight of Product 53747 is approximately 1.5  to 1.8 X 10E6 Dalton.

  4. How should I store Product 53747, Hyaluronic acid sodium salt from Streptococcus equi?

    This product should be stored at - 20 °C.

  5. Can Product 53747, Hyaluronic acid, be sterilized?

    Yes, according to references you can autoclave Hyaluronic acid sodium salt from Streptococcus equi.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Jae-Yong Park et al.
PloS one, 9(11), e112684-e112684 (2014-11-27)
Synovial fluid plays an important role in lubricating synovial joints. Its main constituents are hyaluronic acid (HA) and γ-globulin, acting as boundary lubricants for articular cartilage. The aim of the study was to demonstrate the concentration-dependent effect of HA and
Telma E Santos et al.
Cell reports, 32(3), 107907-107907 (2020-07-23)
During development of the central nervous system (CNS), neurons polarize and rapidly extend their axons to assemble neuronal circuits. The growth cone leads the axon to its target and drives axon growth. Here, we explored the mechanisms underlying axon growth
Tao Jin et al.
Biomaterials, 113, 176-190 (2016-11-07)
Extracellular matrix (ECM) is widely used as an inductive biological scaffold to repair soft tissue after injury by promoting functional site-appropriate remodeling of the implanted material. However, there is a lack of non-invasive analysis methods to monitor the remodeling characteristics
H C Lin et al.
European cells & materials, 40, 133-145 (2020-09-21)
Vascularisation efficiency plays an essential role in the success of bulk transplantation, while biocompatibility and safety are major concerns in clinical applications. Fibrin-based hydrogels have been exploited as scaffolds for their advantages in biocompatibility, degradability and mass transportation in various
Wei-Yao Chen et al.
Frontiers in endocrinology, 12, 572690-572690 (2021-03-30)
The global obesity population is increasing year-by-year, and the related cost is sharply increasing annually. There are several methods available to combat obesity; however, there is a lack of a single tool that is both safe and efficacious. The use
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