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Merck
CN

53747

透明质酸 钠盐 来源于马链球菌

bacterial glycosaminoglycan polysaccharide

别名:

聚（β-葡萄糖醛酸-[1→3]-β-N-乙酰葡糖胺-[1→4]），交替

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关于此项目

化学文摘社编号:
9067-32-7
MDL number:
MFCD00875848
UNSPSC Code:
51202002
PubChem Substance ID:
24878223
NACRES:
NA.25

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产品名称

透明质酸 钠盐 来源于马链球菌, bacterial glycosaminoglycan polysaccharide

SMILES string

[Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2C([O-])=O

InChI

1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1

InChI key

YWIVKILSMZOHHF-QJZPQSOGSA-N

biological source

(Streptococcus equi)

form

powder or crystals

mol wt

~1.5-1.8 x 10E6 Da

impurities

≤1% protein

color

white

solubility

H2O: 5 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

相关类别

Application

马链球菌透明质酸钠盐已用于：
  • 与甲基丙烯酸酐合成交联甲基丙烯酸 HA 水凝胶（Coll-MeHA）
  • 在磷酸盐缓冲盐水（PBS）中取代 PBS 浴槽来改变润滑剂成分
  • 制备润滑剂，以研究对人体骨关节炎（OA）软骨边界润滑的影响

Biochem/physiol Actions

透明质酸（HA）是滑膜液和关节软骨的重要组分，起边界润滑剂的作用。它具有多种物理化学性质，包括生物可降解性、生物相容性、无毒性和非免疫原性。透明质酸被认为是生物医学用途的重要工具，如药物输送、组织工程、整形外科、眼科手术和骨关节炎手术。它参与身体缓冲和润滑。这种强大的抗氧化剂可以将水与组织结合。

General description

透明质酸（HA）是中枢神经系统细胞外基质的重要组分，是在所有脊椎动物结缔组织中都能发现的多功能大分子。这种超分子糖胺聚糖是一种聚阴离子天然聚合物，以线性多糖的形式存在。它由葡萄糖醛酸和N-乙酰氨基葡萄糖通过β-1,4键重复组成。透明质酸在眼睛、关节和心脏瓣膜中大量存在。

Other Notes

为了全面了解我们针对客户研究提供的各种多糖产品，建议您访问我们的碳水化合物分类页面。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000431155
0000431155
0000464558
0000464558
BCCN0155

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the molecular weight of Product 53747, Hyaluronic acid sodium salt from Streptococcus equi?

    According to our supplier, the molecular weight of Product 53747 is approximately 1.5  to 1.8 X 10E6 Dalton.

  4. How should I store Product 53747, Hyaluronic acid sodium salt from Streptococcus equi?

    This product should be stored at - 20 °C.

  5. Can Product 53747, Hyaluronic acid, be sterilized?

    Yes, according to references you can autoclave Hyaluronic acid sodium salt from Streptococcus equi.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Jae-Yong Park et al.
PloS one, 9(11), e112684-e112684 (2014-11-27)
Synovial fluid plays an important role in lubricating synovial joints. Its main constituents are hyaluronic acid (HA) and γ-globulin, acting as boundary lubricants for articular cartilage. The aim of the study was to demonstrate the concentration-dependent effect of HA and
Tao Jin et al.
Biomaterials, 113, 176-190 (2016-11-07)
Extracellular matrix (ECM) is widely used as an inductive biological scaffold to repair soft tissue after injury by promoting functional site-appropriate remodeling of the implanted material. However, there is a lack of non-invasive analysis methods to monitor the remodeling characteristics
Wei-Yao Chen et al.
Frontiers in endocrinology, 12, 572690-572690 (2021-03-30)
The global obesity population is increasing year-by-year, and the related cost is sharply increasing annually. There are several methods available to combat obesity; however, there is a lack of a single tool that is both safe and efficacious. The use
Telma E Santos et al.
Cell reports, 32(3), 107907-107907 (2020-07-23)
During development of the central nervous system (CNS), neurons polarize and rapidly extend their axons to assemble neuronal circuits. The growth cone leads the axon to its target and drives axon growth. Here, we explored the mechanisms underlying axon growth
H C Lin et al.
European cells & materials, 40, 133-145 (2020-09-21)
Vascularisation efficiency plays an essential role in the success of bulk transplantation, while biocompatibility and safety are major concerns in clinical applications. Fibrin-based hydrogels have been exploited as scaffolds for their advantages in biocompatibility, degradability and mass transportation in various
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