52853
7α-羟基-4-胆甾烯-3-酮
≥95.0% (HPLC)
别名:
7α-羟基胆甾-4-烯-3-酮
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关于此项目
经验公式（希尔记法）:
C27H44O2
化学文摘社编号:
分子量:
400.64
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI key
IOIZWEJGGCZDOL-RQDYSCIWSA-N
SMILES string
O=C1CC[C@@]2(C)C(C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)C)=C1
InChI
1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1
grade
analytical standard
assay
≥95.0% (HPLC)
application(s)
clinical testing
format
neat
storage temp.
−20°C
Quality Level
General description
已知7α-羟基-4-胆甾烯-3-酮（C4）是胆固醇7α-羟化酶活性的标志物。在胆汁酸代谢中起重要作用。
Application
C4可作为参比标准品，
- 通过超高效液相色谱-串联质谱法（UHPLC-MS / MS）-电喷雾离子源（ESI）测定人血清中的C4。
- 通过LC-ESI-MS / MS进行多反应监测（MRM）模式检测的大鼠和猴血浆。
- 采用固相萃取（SPE）和HPLC测定外周血血浆。
Biochem/physiol Actions
7a-羟基胆甾-3-酮是胆汁酸合成中的代谢产物，来源于 7a-羟基胆固醇，可进一步代谢为 7a,12a,-二羟基胆甾-4-烯-3-酮，用于分析分析血清中 7a-羟基胆甾烯-3-酮 (HCO) 可能作为一种新型、简便、灵敏的方法用于检测不明原因慢性腹泻患者的胆汁酸吸收障碍。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
LC-MS/MS quantification of 7?-hydroxy-4-cholesten-3-one (C4) in rat and monkey plasma.
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HMG-CoA reductase inhibitors are now the therapy of choice in the treatment of hypercholesterolaemia. The effects of long-term treatment with these substances on plasma lipoproteins, cholesterol metabolism and biliary secretion of lipids have been extensively studied in humans. Much less
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Nonalcoholic steatohepatitis (NASH) is a multifactorial disease involving different contributing mechanisms, with no approved therapies so far. Tropifexor (TXR), a farnesoid X receptor agonist, and cenicriviroc (CVC), a chemokine receptor types 2/5 antagonist, target the steatotic, inflammatory, and/or fibrotic pathways
A UHPLC-MS/MS method for the quantification of 7?-hydroxy-4-cholesten-3-one to assist in diagnosis of bile acid malabsorption.
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Journal of Chromatography. B, Biomedical Sciences and Applications, 1033, 317-320 (2016)
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