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安全信息

50847

Sigma-Aldrich

Gramicidin C from Bacillus brevis

~90% (HPLC)

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About This Item

CAS号:
MDL编号:
UNSPSC代码:
51283112
NACRES:
NA.85

生物来源

Bacillus brevis

质量水平

方案

~90% (HPLC)

表单

powder

杂质

≤5% water

颜色

white to off-white

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

cell membrane | interferes
enzyme | inhibits

储存温度

2-8°C

SMILES字符串

CC(C)C[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(=O)[C@@H]4CCCN4C(=O)[C@@H](Cc5ccccc5)NC1=O)C(C)C)C(C)C

InChI key

IUAYMJGZBVDSGL-JYFSIOBESA-N

一般描述

Chemical structure: peptide

应用

Gramicidin is a naturally occuring polypeptide antibiotic. It functions as a transmembrane ion channel and is used for studies on phospholipid bilayer membrane fluidity measured by lateral diffusion.

生化/生理作用

Gramicidin′s bactericidal activity is a result of increasing the permeability of the bacterial cell membrane. This allows inorganic monovalent cations to travel through unrestricted which thereby destroys the ion gradient between the cytoplasm and the extracellular environment .
Naturally occuring polypeptide antibiotic with Tyr at position 11; functions as a transmembrane ion channel.

包装

10mg

其他说明

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place. Keep in a dry place.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

G.A. Brewer
Anal. Profiles Drug Subst., 8, 179-179 (1979)
Dong Hyeon Lee et al.
Yonsei medical journal, 49(3), 459-471 (2008-06-27)
This study examined the expression and function of inward rectifier K(+) channels in cultured rat hepatic stellate cells (HSC). The expression of inward rectifier K(+) channels was measured using real-time RT-PCR, and electrophysiological properties were determined using the gramicidin-perforated patch-clamp
Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases.
Francisco J. Alvarez-Leefmans; Eric Delpire
Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases, 142-142 (2009)

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