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Merck
CN

50644

Sigma-Aldrich

N-羟乙酰神经氨酸

≥95% (HPLC)

别名:

Neu5Glc, NeuNGl

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About This Item

经验公式(希尔记法):
C11H19NO10
CAS号:
分子量:
325.27
Beilstein:
1716828
MDL编号:
UNSPSC代码:
12352201
PubChem化学物质编号:

生物来源

synthetic

质量水平

方案

≥95% (HPLC)

表单

powder

储存温度

−20°C

SMILES字符串

[H][C@]1(O[C@@](O)(C[C@H](O)[C@H]1NC(=O)CO)C(O)=O)[C@H](O)[C@H](O)CO

InChI

1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/t4-,5+,7+,8+,9+,11-/m0/s1

InChI key

FDJKUWYYUZCUJX-AJKRCSPLSA-N

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应用

甘氨酰神经氨酸,一种非人类乳汁和初乳的成分,被用作引用来分析泌乳期中甘氨酸的变化。甘氨酰神经氨酸是一种异种抗原,在异种移植过程中参与抗原反应(抗体介导的超急性排斥反应)。

其他说明

为了全面了解我们针对客户研究提供的各种单糖产品,建议您访问我们的碳水化合物分类页面。
N-羟乙酰神经氨酸在大鼠和小鼠肝脏中生物合成的调节
销售限制可能适用

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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A Lepers et al.
European journal of biochemistry, 193(3), 715-723 (1990-11-13)
The relative contribution of N-glycoloyl-beta-D-neuraminic acid (Neu5Gc) to total sialic acids expressed in mouse and rat liver glycoconjugates was found to be 95% and 11%, respectively. This considerable difference in sialic acid composition made these two tissues suitable models for
Rachel E Taylor et al.
The Journal of experimental medicine, 207(8), 1637-1646 (2010-07-14)
The nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc) is metabolically incorporated into human tissues from certain mammalian-derived foods, and this occurs in the face of an anti-Neu5Gc "xeno-autoantibody" response. Given evidence that this process contributes to chronic inflammation in some diseases
Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk.
Vered Padler-Karavani et al.
Xenotransplantation, 18(1), 1-5 (2011-02-24)
Qiaozhen Lu et al.
Analytical chemistry, 84(6), 2761-2768 (2012-03-07)
Human polyclonal IgG antibodies directly against the nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc) are potential biomarkers and mechanistic contributors to cancer and other diseases associated with chronic inflammation. Using a sialoglycan microarray, we screened the binding pattern of such antibodies
Véronique Spichtig et al.
Analytical biochemistry, 405(1), 28-40 (2010-06-18)
Sialic acids are becoming recognized as important components of milk-based products for infants and young children. As such, many companies now label the sialic acid content of their products. To control the labeling, suitable methods are required for this analysis.

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