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安全信息

490M-1

Tyrosine Hydroxylase (LNC1) Mouse Monoclonal Antibody

别名:

TYH

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About This Item

UNSPSC代码:
41116161

生物来源

(Mouse)

质量水平

500

偶联物

unconjugated

抗体形式

(IgG1 Supernatant)

抗体产品类型

primary antibodies

克隆

LNC1

描述

For In Vitro Diagnostic Use in Select Regions

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL (concentrate (490M-14))
vial of 0.1 mL (concentrate (490M-14-RUO) Research Use Only)
vial of 0.5 mL (concentrate (490M-15))
vial of 1.0 mL (concentrate (490M-16))
vial of 1.0 mL (concentrate (490M-16-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute (490M-17-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute ready-to-use (490M-17))
vial of 7.0 mL (pre-dilute ready-to-use (490M-18))
vial of 7.0 mL (pre-dilute ready-to-use (490M-18-RUO) Research Use Only)

制造商/商品名称

Cell Marque®

技术

immunohistochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:25-1:100 (concentrated))

同位素/亚型

IgG1

控制

neuroblastoma

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic

一般描述

Tyrosine Hydroxylase (TYH) is the rate-limiting enzyme of catecholamine biosynthesiss. TYH uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-DOPA, a precursor to dopamine. Anti-TYH is sensitive and specific for peripheral neuroblastic tumors in the differential diagnosis from other tumors of childhood and shows high diagnostic utility. Anti-TYH has been shown to positively label all pheochromocytomas and sympathetic paragangliomas, and thus aids in differentiating them from their histologic mimics such as adrenocortical neoplasms.

质量

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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L A Loizou
British journal of pharmacology, 41(1), 41-48 (1971-01-01)
1. Tyrosine hydroxylase is thought to be the rate limiting enzyme step in catecholamine biosynthesis. Inhibition of this enzyme using alpha-methyl-p-tyrosine resulted in a time dependent depletion (and repletion) of formaldehyde induced fluorescence in catecholamine-containing neurones of the central nervous
Junkichi Takemoto et al.
Human pathology, 85, 162-167 (2018-11-24)
The RNA-binding protein HuC/D displays a neuron-specific expression and is involved in neuronal differentiation and the maintenance of the nervous system. Here we investigated the diagnostic value of HuC/D in neuroblastomas. We evaluated 85 neuroblastic tumors: 81 neuroblastomas; 3 ganglioneuroblastomas
Mikako Warren et al.
Histopathology, 72(4), 685-696 (2017-10-08)
This study evaluated the utility of Phox2b in paediatric tumours. Previously, tyrosine hydroxylase (TH) was the most widely utilised sympathoadrenal marker specific for neural crest tumours with neuronal/neuroendocrine differentiation. However, its sensitivity is insufficient. Recently Phox2b has emerged as another
S Colette Daubner et al.
Archives of biochemistry and biophysics, 508(1), 1-12 (2010-12-24)
Tyrosine hydroxylase is the rate-limiting enzyme of catecholamine biosynthesis; it uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino terminal 150 amino acids comprise a domain whose structure is involved in regulating the enzyme's activity. Modes of

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