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安全信息

484R-1

Sigma-Aldrich

PRAME (EP461) Rabbit Monoclonal Primary Antibody

别名:

Preferentially-expressed Antigen in Melanoma

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About This Item

UNSPSC代码:
12352203

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP461, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形式

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (484R-14)
vial of 0.1 mL concentrate Research Use Only (484R-14-RUO)
vial of 0.5 mL concentrate (484R-15)
vial of 1.0 mL concentrate (484R-16)
vial of 1.0 mL concentrate Research Use Only (484R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (484R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (484R-17)
vial of 25.0 mL pre-dilute ready-to-use Research Use Only (484R-10-RUO)
vial of 25.0 mL pre-dilute ready-to-use (484R-10)
vial of 7.0 mL pre-dilute ready-to-use (484R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (484R-18-RUO)

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)

同位素/亚型

IgG

控制

melanoma

运输

wet ice

储存温度

2-8°C

可视化

nuclear

相关类别

一般描述

PRAME (PReferentially-expressed Antigen in MElanoma) is a gene encoded on the 22q11-22 chromosomal sequence and encodes a 509 amino acid residue protein.1 PRAME is a melanoma antigen that is preferentially expressed in tumors and is recognized by cytotoxic T lymphocytes.2,3 PRAME can be used to distinguish between malignant melanoma cells and nevus cells,4 and therefore may be useful for diagnostic purposes to support a suspected case of melanoma. PRAME is considered a cancer-testis antigen (CTA)5 and is not strongly expressed in most other normal tissues. PRAME is positively expressed in about half of uveal melanomas,6 and the majority of mucosal melanomas.7

质量

  • United States - IVD
  • Canada - RUO
  • European Union - IVD
  • Japan - RUO

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and < 0.1% Sodium Azide.

制备说明

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其他说明

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WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Frances Wadelin et al.
Molecular cancer, 9, 226-226 (2010-08-31)
PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid
Aimi Toyama et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 32(12), 1727-1733 (2019-08-04)
Mucosal melanomas are rare, and less is known about the biomarkers of this subtype in comparison to cutaneous or uveal melanomas. Preferentially expressed antigen in melanoma (PRAME) has been studied as a tool for prognostication of uveal melanomas, and immunotherapy
Wa Zhang et al.
Oncotarget, 7(29), 45352-45369 (2016-06-21)
PRAME is a cancer-testis antigen (CTA) and potential immuno-therapeutic target, but has not been well-studied in epithelial ovarian cancer (EOC) or its high grade serous (HGSC) subtype. Compared to normal ovary, PRAME expression was significantly increased most EOC, regardless of
H Ikeda et al.
Immunity, 6(2), 199-208 (1997-02-01)
Melanoma lines MEL.A and MEL.B were derived from metastases removed from patient LB33 in 1988 and 1993, respectively. The MEL.A cells express several antigens recognized by autologous cytolytic T lymphocytes (CTL) on HLA class I molecules. The MEL.B cells have
Cecilia Lezcano et al.
The American journal of surgical pathology, 42(11), 1456-1465 (2018-07-26)
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen that was isolated by autologous T cells in a melanoma patient. While frequent PRAME mRNA expression is well documented in cutaneous and ocular melanomas, little is known about PRAME protein
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