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安全信息

482R-1

Sigma-Aldrich

p63 (EP174) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSC代码:
12352203

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP174

描述

For In Vitro Diagnostic Use in Select Regions

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (482R-14)
vial of 0.1 mL concentrate, Research Use Only (482R-14-RUO)
vial of 0.5 mL concentrate (482R-15)
vial of 1.0 mL concentrate (482R-16)
vial of 1.0 mL concentrate, Research Use Only (482R-16-RUO)
vial of 1.0 mL pre-dilute ready-to-use, Research Use Only (482R-17-RUO)
vial of 1.0 mL pre-dilute, ready to use (482R-17)
vial of 25.0 mL pre-dilute ready-to-use (482R-10)
vial of 25.0 mL pre-dilute ready-to-use, Research Use Only (482R-10-RUO)
vial of 7.0 mL pre-dilute, ready to use (482R-18)
vial of 7.0 mL pre-dilute, ready to use, Research Use Only (482R-18-RUO)

制造商/商品名称

Cell Marque

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (1:100-1:200 (concentrated))

同位素/亚型

IgG

控制

lung (squamous cell carcinoma), prostate

运输

wet ice

储存温度

2-8°C

可视化

nuclear

一般描述

p63 is a transcription factor that regulates many cell activities, including cell proliferation, maintenance, differentiation, adhesion, and apoptosis.1 It has been found to be a sensitive and specific marker of myoepithelial and basal cell populations in prostate, breast, skin, and salivary gland. Additionally, p63 has also demonstrated immunohistochemical utility in identifying benign and malignant breast lesions.2 In prostatic carcinomas, it can also be used to recognize benign glands adjacent to malignant glands.3 p63 can also be used to differentiate adenocarcinoma of the lungs, where it is usually negative, from squamous cell carcinoma, which can be useful for advanced stages of the carcinoma where surgery is no longer an option.4

质量

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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D Stefanou et al.
Histology and histopathology, 19(2), 465-471 (2004-03-17)
The p63 gene encodes six protein isoforms. The transactivating isoforms have similar actions with p53, while the N-isoforms inhibit transcription activation by p53 and transactivating isoforms. p63 is expressed in stratified epithelia and in basal cells of the prostate and
Ricardo Camilo et al.
Human pathology, 37(5), 542-546 (2006-05-02)
In this study, we sought to validate the importance of p63, CK5/CK6, CK7, and surfactant-A (SP-A) to classify 42 non-small cell lung cancers in autopsy and surgical resection specimens and to study the usefulness of these markers in distinguishing between
Zhong Jiang et al.
American journal of clinical pathology, 123(2), 231-236 (2005-04-22)
We assessed the usefulness of immunohistochemical analysis with a 3-antibody cocktail (alpha-methylacyl coenzyme A racemase [AMACR, or P504S], 34betaE12, p63) and a double-chromogen reaction for detection of limited prostate cancer in 138 needle biopsy specimens, including 82 with small foci
A Yang et al.
Molecular cell, 2(3), 305-316 (1998-10-17)
We describe the cloning of p63, a gene at chromosome 3q27-29 that bears strong homology to the tumor suppressor p53 and to the related gene, p73. p63 was detected in a variety of human and mouse tissues, including proliferating basal

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