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Merck
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安全信息

468R-1

Sigma-Aldrich

Claudin-4 (EP417) Rabbit Monoclonal Primary Antibody

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UNSPSC代码:
12352203

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP417, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形式

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (468R-14)
vial of 0.1 mL concentrate Research Use Only (468R-14-RUO)
vial of 0.5 mL concentrate (468R-15)
vial of 1.0 mL concentrate (468R-16)
vial of 1.0 mL concentrate Research Use Only (468R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (468R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (468R-17)
vial of 7.0 mL pre-dilute ready-to-use (468R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (468R-18-RUO)

制造商/商品名称

Cell Marque™

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 (concentrated)

同位素/亚型

IgG

控制

lung adenocarcinoma

运输

wet ice

储存温度

2-8°C

可视化

membranous

基因信息

human ... CLDN4(1364)

相关类别

一般描述

The claudin-family proteins are a group of tight-junction membranous proteins responsible for paracellular molecular flow between adjacent cells of the epithelium.1 In normal kidney, claudin-4 plays a key role in paracellular ion reabsorption.2 Claudin-4 is expressed in most epithelial cells yet is absent in mesothelial cells, making it of great use in characterizing epithelial malignincies.3 Immunohistochemical identification of this antigen may help identify poorly differentiated lung adenocarcinoma from lesions of mesothelial origin.4 Likewise, identification of claudin-4 expression by IHC may be useful in characterizing breast and endometrial lesions.5,6

质量

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

法规信息

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Xin Cong et al.
Journal of cell science, 128(12), 2271-2286 (2015-05-08)
The epithelial cholinergic system plays an important role in water, ion and solute transport. Previous studies have shown that activation of muscarinic acetylcholine receptors (mAChRs) regulates paracellular transport of epithelial cells; however, the underlying mechanism is still largely unknown. Here
A Neesse et al.
Archives of biochemistry and biophysics, 524(1), 64-70 (2012-01-31)
Intercellular junctional complexes such as adherens junctions and tight junctions are critical regulators of cellular polarity, paracellular permeability and metabolic and structural integrity of cellular networks. Abundant expression analysis data have yielded insights into the complex pattern of differentially expressed
Jianghui Hou et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(42), 18010-18015 (2010-10-06)
Tight junctions (TJs) play a key role in mediating paracellular ion reabsorption in the kidney. The paracellular pathway in the collecting duct of the kidney is a predominant route for transepithelial chloride reabsorption that determines the extracellular NaCl content and
Gottfried E Konecny et al.
Gynecologic oncology, 109(2), 263-269 (2008-03-04)
Tight junction (TJ) proteins claudin-3 and claudin-4 may be differentially expressed in uterine serous papillary carcinoma (USPC), a rare form of endometrial cancer characterized by a particularly poor prognosis. Our aim was to determine the expression pattern and prognostic relevance
Nelson G Ordóñez
American journal of clinical pathology, 139(5), 611-619 (2013-04-19)
Claudin-4 (CL-4) is a tight junction-associated protein that is expressed in most epithelial cells but absent in mesothelial cells. The purpose of this study is to evaluate the utility of CL-4 immunostaining for assisting in the differential diagnosis of mesothelioma.
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