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安全信息

466R-1

Sigma-Aldrich

SDHB (EP288) Rabbit Monoclonal Primary Antibody

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别名:
Succinate dehydrogenase B
UNSPSC代码:
12352203

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP288, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形式

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (466R-14)
vial of 0.1 mL concentrate Research Use Only (466R-14-RUO)
vial of 0.5 mL concentrate (466R-15)
vial of 1.0 mL concentrate (466R-16)
vial of 1.0 mL concentrate Research Use Only (466R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (466R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (466R-17)
vial of 7.0 mL pre-dilute ready-to-use (466R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (466R-18-RUO)

制造商/商品名称

Cell Marque™

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同位素/亚型

IgG

控制

GIST

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic

基因信息

human ... SDHB(6390)

相关类别

一般描述

Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane. Many cancers are generally positive for SDHB, including renal cell carcinomas (RCC) and gastrointestinal stromal tumors (GIST). However, a subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.

质量


IVD
IVD
IVD
RUO

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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H C Au et al.
Gene, 159(2), 249-253 (1995-07-04)
The iron-sulfur protein (Ip) subunit of succinate dehydrogenase (SDH and complex II) of the respiratory chain is highly conserved in evolution [Gould et al., Proc. Natl. Acad. Sci. USA 86 (1989) 1934-1938]. We have cloned the entire human Ip cDNA
Anthony J Gill et al.
Human pathology, 41(6), 805-814 (2010-03-20)
Up to 30% of pheochromocytomas and paragangliomas are associated with germline RET, Von Hippel-Lindau (VHL), neurofibromatosis type I (NF1), and succinate dehydrogenase subunits (SDHB, SDHC, and SDHD) mutations. Genetic testing allows familial counseling and identifies subjects at high risk of
Sean R Williamson et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 28(1), 80-94 (2014-07-19)
Patients with germline mutation of succinate dehydrogenase (SDH) subunit genes are prone to develop paraganglioma, gastrointestinal stromal tumor, and rarely renal cell carcinoma (RCC). However, SDH-deficient RCC is not yet widely recognized. We identified such tumors by distinctive morphology and
José Gaal et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(1), 147-151 (2010-10-05)
Mutations in the tumor suppressor genes SDHB, SDHC, and SDHD (or collectively SDHx) cause the inherited paraganglioma syndromes, characterized by pheochromocytomas and paragangliomas. However, other tumors have been associated with SDHx mutations, such as gastrointestinal stromal tumors (GISTs) specifically in

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