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Merck
CN
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主要文件

安全信息

465R-1

Sigma-Aldrich

TROP2 (EP431) Rabbit Monoclonal Primary Antibody

别名:

Trophoblast Antigen 2

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About This Item

UNSPSC代码:
12352203

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP431, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (465R-14)
vial of 0.1 mL concentrate Research Use Only (465R-14-RUO)
vial of 0.5 mL concentrate (465R-15)
vial of 1.0 mL concentrate (465R-16)
vial of 1.0 mL concentrate Research Use Only (465R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (465R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (465R-17)
vial of 7.0 mL pre-dilute ready-to-use (465R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (465R-18-RUO)

制造商/商品名称

Cell Marque™

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同位素/亚型

IgG

控制

papillary carcinoma of thyroid

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic, membranous

基因信息

human ... TACSTD2(4070)

相关类别

一般描述

Trophoblast antigen 2 (TROP2) is a transmembrane glycoprotein that transduces intracellular calcium signals. The overexpression of TROP2 has been linked to tumor progression due to its involvement in the regulation of multiple vital cell processes including migration, proliferation, and invasion. TROP2 exhibits strong, diffuse staining in papillary thyroid carcinoma, while staining in other thyroid lesions, such as follicular thyroid adenomas and carcinomas, is limited to rare, focal, or scattered cells. An increase in TROP2 expression has also been observed in colorectal carcinomas and ovarian serous carcinomas compared to non-neoplastic ovary and colon.

质量


IVD
IVD
IVD
RUO

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

法规信息

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分析证书(COA)

Lot/Batch Number
0000406949
0000377573
0000366879
0000357629
0000354673

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访问文档库

Andrey Bychkov et al.
Pathology, 48(5), 425-433 (2016-06-18)
We aimed to evaluate the diagnostic utility of the novel immunohistochemical marker TROP-2 on thyroid specimens (226 tumours and 207 controls). Whole slide immunohistochemistry was performed and scored by automated digital image analysis. Non-neoplastic thyroid, follicular adenomas, follicular carcinomas, and
Haiyan Liu et al.
Applied immunohistochemistry & molecular morphology : AIMM, 25(8), 525-533 (2016-02-11)
Human trophoblast cell-surface marker (TROP-2) has been reported to be overexpressed in various human carcinomas (CAs) and suggested to be a prognostic marker for some CAs. The diagnostic utility of TROP-2 in CAs has not been explored. Immunohistochemical evaluation of
E Ripani et al.
International journal of cancer, 76(5), 671-676 (1998-06-04)
Trop-2/EGP-1/GA733-1 is a recently identified cell surface glycoprotein highly expressed by human carcinomas. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Thus, we investigated whether Trop-2 might be a functional
Lara P Stepan et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 59(7), 701-710 (2011-05-10)
Trop2 is a cell-surface glycoprotein reported to be overexpressed in various types of adenocarcinomas with minimal expression in normal tissues. Recent findings that Trop2 expression correlates with tumor aggressiveness have increased interest in Trop2 as a potential target for cancer
Bin Wu et al.
Experimental and therapeutic medicine, 14(3), 1947-1952 (2017-10-01)
Human trophoblastic cell-surface marker, tumor-associated calcium signal transducer 2 (TROP2), is a newly identified marker that has a vital role in the proliferation and invasion of various tumors. However, its specific function in ovarian cancer has not been researched. The

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